Inspiratory Muscle Strength Training in Adults With Type 2 Diabetes (DIT)
Diabetes Mellitus, Type 2, Hypertension
About this trial
This is an interventional basic science trial for Diabetes Mellitus, Type 2 focused on measuring insulin sensitivity, blood pressure, blood glucose, non-pharmacological, inspiratory resistance training
Eligibility Criteria
Inclusion Criteria: diagnosed with type 2 diabetes by physician fasting plasma glucose levels ≥126 mg/dl and ≤240 mg/dl systolic blood pressure between 120-169 mmHg stable dose of medication (three months on the same dose) weight stable in the prior 3 months (<3.0 kg weight change) and willing to remain weight stable throughout the study absence of unstable clinical disease as determined by medical history Exclusion Criteria: current smoker (including tobacco products, vaping devices, THC, etc…) have an uncontrolled medical condition (e.g., cancer) myocardial infarction or stroke within the previous 12 months performs regular aerobic exercise (>4 bouts/week) BMI ≥ 40 kg/m2 systolic blood pressure <120 or ≥170 mmHg diastolic blood pressure >100 or <60 mmHg Cheyne-Stokes respiration history of perforated eardrum history of glaucoma or retinopathy history of collapsed lung diagnosed with asthma pregnant, breastfeeding, or trying to become pregnant (self-reported) medications that, in the opinion of the study physician or nurse practitioner, may impact the outcomes of the study (e.g., steroids)
Sites / Locations
- Arizona Respiratory and Neurophysiology Laboratory
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
High-resistance IMST
Low-resistance IMST
30 breaths/day (5 sets of 6 breaths, one minute of rest between sets), 5 days/week, 6 weeks
30 breaths/day (5 sets of 6 breaths, one minute of rest between sets), 5 days/week, 6 weeks