Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.
Insulin Resistance, Age Problems
About this trial
This is an interventional prevention trial for Insulin Resistance
Eligibility Criteria
Inclusion Criteria:
- Healthy volunteers
- Aged 18-35 or 65-85
- Male
Exclusion Criteria:
- Current participation in a formal exercise regime
- A BMI < 18 or > 32 kg·m2
Active cardiovascular disease:
o uncontrolled hypertension (BP > 160/100), angina, heart failure (class III/IV), Significant arrhythmia, right to left cardiac shunt, recent cardiac event
- Taking beta-adrenergic blocking agents,
Cerebrovascular disease:
o previous stroke, aneurysm (large vessel or intracranial), epilepsy
Respiratory disease including:
o pulmonary hypertension, significant COPD, uncontrolled asthma,
Metabolic disease:
o hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, type 1 or 2 diabetes
- Active inflammatory bowel or renal disease
- Malignancy
- Clotting dysfunction
- Significant musculoskeletal or neurological disorders
- Family history of early (<55y) death from cardiovascular disease
Sites / Locations
- University Of Nottingham
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Older Men
Younger Men
Healthy male adults aged 18-35 Subjects will receive both HMB and placebo on separate visits in a crossover fashion
Healthy male adults aged 65-85 Subjects will receive both HMB and placebo on separate visits in a crossover fashion