Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics
Hypertension
About this trial
This is an interventional basic science trial for Hypertension focused on measuring Hypertension, Sevoflurane, Inhaled Anesthetic, Angiotensin Converting Enzyme Inhibitor, Angiotensin II Receptor Blocking Agent
Eligibility Criteria
Inclusion Criteria:
- age over 40
- composite head and neck tumor resection
- treated hypertension
- hypertension medications taken on morning of surgery (except diuretics)
Exclusion Criteria:
- patient refusal
- age less than 40 or over 80 years
- combined surgical procedures
- emergency surgery
- Left ventricular ejection fraction less than 50 per cent
- calculated creatinine clearance less than 60 mL per minute
Sites / Locations
- London Health Sciences Centre - Victoria CampusRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
Angiotensin Converting Enzyme Exposed
Angiotensin Receptor Blocker Exposed
Non ACE/ARB Exposed
Sevoflurane/oxygen/air/nitrous oxide Hypertensive patients exposed to Angiotensin Converting Enzyme Inhibitors (ACE Inhibitors)will make up this arm. Preoperative Exposure to any of the following Angiotensin Converting Enzyme Inhibitors Enalapril (Vasotec/Renitec) Ramipril (Altace/Prilace/Ramace/Ramiwin/Triatec/Tritace) Quinapril (Accupril) Perindopril (Coversyl/Aceon) Lisinopril (Listril/Lopril/Novatec/Prinivil/Zestril) Benazepril (Lotensin) Imidapril (Tanatril) Zofenopril (Zofecard) Trandolapril (Mavik/Odrik/Gopten) Fosinopril (Fositen/Monopril)
Sevoflurane/oxygen/air/nitrous oxide Hypertensive patients exposed to Angiotensin Receptor Blocking Agents (ARBs). Preoperative Exposure to any of the following Angiotensin II Receptor Blocking Agents Losartan(Cozaar) Candesartan (Atacand) Valsartan (Diovan) Irbesartan (Avapro) Telmisartan (Micardis) Eprosartan (Teveten) Olemisartan (Benicar) Azilsartan (Edarbi)
Sevoflurane/oxygen/air/nitrous oxide Hypertensive patients not exposed to angiotensin converting enzyme inhibitors or Angiotensin receptor blocking agents will be put into this arm.