Job Strain, Ambulatory Blood Pressure and Hypertension
Primary Purpose
Cardiovascular Diseases, Cerebrovascular Accident, Hypertension
Status
Completed
Phase
Locations
Study Type
Observational
Intervention
Sponsored by
About this trial
This is an observational trial for Cardiovascular Diseases
Eligibility Criteria
No eligibility criteria
Sites / Locations
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT00005472
First Posted
May 25, 2000
Last Updated
May 12, 2016
Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
1. Study Identification
Unique Protocol Identification Number
NCT00005472
Brief Title
Job Strain, Ambulatory Blood Pressure and Hypertension
Study Type
Observational
2. Study Status
Record Verification Date
August 2004
Overall Recruitment Status
Completed
Study Start Date
September 1996 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
August 1998 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
4. Oversight
5. Study Description
Brief Summary
To analyze the association between an objective measure of "job strain" and risk of stroke, and change in ambulatory blood pressure.
Detailed Description
BACKGROUND:
Cardiovascular disease accounts for 43 percent of all deaths in the United States. Hypertension affects as many as 50 million Americans, however the causes of essential hypertension are not well known. A new CVD risk factor ("job strain") has emerged as a potential major cause of essential hypertension. By 1995, over 20 studies had found significant positive relationships between "job strain" and CVD, coronary heart disease, all-cause mortality or hypertension. "Job strain" is defined as high psychological workload demands combined with low"decision latitude". An expanded concept of "job strain" which included low workplace social support ("iso-strain") was developed and examined in the study.
Important questions remained to be answered about "job strain", CVD and hypertension. In most studies, "job strain" was only measured at one point in time, while, in fact, cumulative exposure to "job strain" was believed to be the risk factor. In addition, most studies relied on self-report measures of "job strain". Also, no studies specifically examined risk of stroke and "job strain".
DESIGN NARRATIVE:
Data from the Cornell University cohort study of Psychosocial Factors and Cardiovascular Disease and the Columbia University-Northern Manhattan Stroke Study were analyzed. The study had five specific aims, including to determine whether: blood pressure levels were associated with cumulative exposure to "job strain"; differences in blood pressure increases were associated with an objective measure of "job strain"; increased risk of stroke was associated with an objective measure of "job strain"; changes in psychological variables over time were associated with job characteristics; changes in CVD risk factors (other than hypertension) were associated with job characteristics.
Paul Landsbergis also constructed measures of cumulative exposure to "job strain" and determined their association with blood pressure, and analyzed the association between job characteristics and change in psychological variables and cardiovascular disease (CVD) risk factors.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cardiovascular Diseases, Cerebrovascular Accident, Hypertension, Heart Diseases
7. Study Design
10. Eligibility
Sex
Male
Maximum Age & Unit of Time
100 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
No eligibility criteria
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Paul Landsbergis
Organizational Affiliation
Weill Medical College of Cornell University
12. IPD Sharing Statement
Citations:
PubMed Identifier
11211061
Citation
Friedman R, Schwartz JE, Schnall PL, Landsbergis PA, Pieper C, Gerin W, Pickering TG. Psychological variables in hypertension: relationship to casual or ambulatory blood pressure in men. Psychosom Med. 2001 Jan-Feb;63(1):19-31. doi: 10.1097/00006842-200101000-00003.
Results Reference
background
PubMed Identifier
12448355
Citation
Landsbergis PA, Schnall PL, Pickering TG, Schwartz JE. Validity and reliability of a work history questionnaire derived from the Job Content Questionnaire. J Occup Environ Med. 2002 Nov;44(11):1037-47. doi: 10.1097/00043764-200211000-00010.
Results Reference
background
PubMed Identifier
12828390
Citation
Landsbergis PA, Schnall PL, Pickering TG, Warren K, Schwartz JE. Lower socioeconomic status among men in relation to the association between job strain and blood pressure. Scand J Work Environ Health. 2003 Jun;29(3):206-15. doi: 10.5271/sjweh.723.
Results Reference
background
PubMed Identifier
12777363
Citation
Landsbergis PA, Schnall PL, Pickering TG, Warren K, Schwartz JE. Life-course exposure to job strain and ambulatory blood pressure in men. Am J Epidemiol. 2003 Jun 1;157(11):998-1006. doi: 10.1093/aje/kwg095.
Results Reference
background
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Job Strain, Ambulatory Blood Pressure and Hypertension
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