Ketogenic Diet Treatment of Obesity With Co-morbid Type 2 Diabetes Mellitus and/or Obstructive Sleep Apnea (KGDobesity)

This is an interventional treatment trial for Obesity focused on measuring ketogenic diet, obesity, diabetes, obstructive sleep apnea Read More

Inclusion Criteria:

• age 18-70
• ability and willingness to signed informed consent form
• BMI more than 30kg/m2, with type 2 DM and/or OSA
• For diabetic participants, stable hypoglycemic medications for at least 2 months
• For participants with OSA, previously documented polysomnogram with apnea/hypopnea index (AHI)>15/h.

Exclusion Criteria:

• BMI change of +/- 3.0 kg/m2 of baseline BMI within past 12 months.
• History of bariatric surgery ≤ 3 years prior to enrollment.
• Any systemic illness or unstable medical condition that might pose additional risk, including: cardiac, unstable metabolic or endocrine disturbances, renal or liver disease, past history of renal calculi, hyperuricemia, hypercalcemia, mitochondrial disease, known disorder of fatty acid metabolism, porphyria, and active systemic cancer.
• History of uncontrolled hyperlipidemia
• For participants with DM, change in the dose or type of hypoglycemic treatment within 2 months prior to enrollment.
• Psychosis within six months of enrollment, evidenced by treatment with anti-psychotic medications with recent medication initiation or dose increase.
• Active drug or alcohol dependence or any other factors that, in the opinion of the site investigators would interfere with adherence to study requirements;
• History of hyperthyroidism
• History of glaucoma
• History of cerebrovascular disease or unstable heart disease within 6 months of enrollment
• Pregnancy
• Use of any investigational drugs within 3 months of enrollment.
• Inability or unwillingness of subject to give written informed consent.