Ketone Ester and Acute Salt (KEAS) in Young Adults (KEAS)
Salt; Excess, Hypertension
About this trial
This is an interventional basic science trial for Salt; Excess
Eligibility Criteria
Inclusion Criteria:
- Between the ages of 18-39
- Resting blood pressure no higher than 150/90
- BMI below 35 kg/m2 (or otherwise healthy)
- Free of any metabolic disease (diabetes or renal), pulmonary disorders (COPD or cystic fibrosis), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer
- Do not have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood
- Participants must be able to cycle on an exercise bike for up to one hour at a time.
Exclusion Criteria:
- High blood pressure - greater the 150/90 mmHg
- Low blood pressure - less than 90/50 mmHg
- History of cardiovascular disease
- History of cancer
- History of diabetes
- History of kidney disease
- Obesity (BMI > 30 kg/m2)
- Smoking or tobacco use
- Current pregnancy
- Nursing mothers
- Communication barriers
Sites / Locations
- Auburn UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Active Comparator
Experimental
No Salt, No β-OHB
High Salt, No β-OHB
High Salt, High β-OHB
Participants will consume the supplemental intervention for 10 days. On day 10 participants will arrive at the laboratory where the investigators will assess resting blood pressure, arterial stiffness, endothelial function, renal blood flow, and submaximal exercise blood pressure reactivity. Blood will be collected to investigate inflammatory and immune responses to the dietary conditions. Starting on day 9, participants will undergo ambulatory blood pressure monitoring and 24-hour urine collection.
Participants will consume the supplemental intervention for 10 days. On day 10 participants will arrive at the laboratory where the investigators will assess resting blood pressure, arterial stiffness, endothelial function, renal blood flow, and submaximal exercise blood pressure reactivity. Blood will be collected to investigate inflammatory and immune responses to the dietary conditions. Starting on day 9, participants will undergo ambulatory blood pressure monitoring and 24-hour urine collection.
Participants will consume the supplemental intervention for 10 days. On day 10 participants will arrive at the laboratory where the investigators will assess resting blood pressure, arterial stiffness, endothelial function, renal blood flow, and submaximal exercise blood pressure reactivity. Blood will be collected to investigate inflammatory and immune responses to the dietary conditions. Starting on day 9, participants will undergo ambulatory blood pressure monitoring and 24-hour urine collection.