Left Atrial Appendage Occlusion Study III (LAAOS III)
Cardiac Surgery With Cardiopulmonary Bypass, Atrial Fibrillation
About this trial
This is an interventional prevention trial for Cardiac Surgery With Cardiopulmonary Bypass focused on measuring cardiac surgery, left atrial appendage, atrial fibrillation, stroke, non-CNS systemic embolism
Eligibility Criteria
Inclusion Criteria:
- Greater than 18 years of age
- Undergoing a clinically indicated cardiac surgical procedure with the use of cardiopulmonary bypass
- Have a documented history of atrial fibrillation or atrial flutter
- CHA2DS2-VASc score ≥ 2
- Have provided informed consent
Exclusion Criteria:
- Patients undergoing off-pump cardiac surgery
Patients undergoing any of the following procedures:
- heart transplant
- complex congenital heart surgery
- sole indication for surgery is ventricular assist device insertion
- previous cardiac surgery requiring opening of the pericardium
- mechanical valve implant
- Patients who have had a previous placement of a percutaneous left atrial appendage closure device
Sites / Locations
- Hamilton General Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Left Atrial Appendage Occlusion Group
No Left Atrial Appendage Occlusion Group
Surgeon will close the left atrial appendage using a suture and/or a surgical stapler or a regulatory approved atrial appendage closure device during the patient's cardiac surgery procedure.
Surgeon will not close the left atrial appendage during the patient's cardiac surgery procedure. Patient will be treated as per best medical practice for stroke prevention in atrial fibrillation. Treatment will be decided by the patient's primary care physician.