Low Dose Aspirin in the Prevention of Preeclampsia in China (APPEC)
Preeclampsia
About this trial
This is an interventional prevention trial for Preeclampsia focused on measuring preeclampsia, low dose aspirin, prevention
Eligibility Criteria
Inclusion Criteria:
- Gestational age between 12+ and 20 weeks of pregnancy
High risk of preeclampsia, based in clinical risk factors as:
2.1 if they have one or more of the following risk factors: Preeclampsia in a previous pregnancy ,Diabetes Mellitus(Type 1 or 2),Chronic Hypertension .
2.2 if they have two or more of the following risk factors: Pre-pregnancy Body Mass Index ≥28kg/m2, Elderly pregnancy(age ≥35 years), Mother or sisters with preeclampsia in a previous pregnancy, Primiparity or Famliy history (Mother or sister that developed preeclampsia in a previous pregnancy).
- Signed informed consent.
Exclusion Criteria:
- Allergy to aspirin
- Asthma
- Peptic ulcers
- Severe heart, liver, renal disease who can not burden the experiment
- Rheumatic immune disease
- Mental disease
- Alcohol and drug abuse
- Being in another drug experiment within 3 months
- Difficult to follow-up
Sites / Locations
- Peking University First Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Other
aspirin
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Low dose aspirin (100 mg) starting between 12+ and 20 weeks of pregnancy until 34 weeks of pregnancy, taking at night.
Routine examination during pregnancy.