Low-load Resistance Training With Blood Flow Restriction in People With Parkinson's Disease (BFR-PD)
Parkinson Disease
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Parkinson Disease, Blood Flow Restriction, Low-load resistance training
Eligibility Criteria
Inclusion Criteria: Adults ages 18-89 with neurologist-confirmed diagnosis of PD H&Y Stage 2 (bilateral involvement without postural instability) up to H&Y Stage 4 (severe disease) Complete Timed up and Go test in ≥ 11 seconds Able to provide informed consent Exclusion Criteria: H&Y Stage 1 (unilateral involvement only) or less H&Y Stage 5 (wheelchair or bed bound) Completes the Timed up and Go in < 11 seconds Unable to provide consent or diagnosis of dementia History of deep venous thrombosis/pulmonary embolism, peripheral vascular disease, thrombophilia or other clotting disorders; report of easy bruising Any comorbid conditions or pain that substantially affects ability to safely complete rehabilitation (e.g. neurologic, vascular, cardiac problems, orthopedic, or ongoing medical treatments) as determined by a neurologist or physical therapist Currently undergoing supervised resistance training with a physical therapist or other exercise professional Using Blood Flow Restriction currently or in the previous 3 months prior to enrollment Cannot tolerate BFR pressure cuff inflated to 60% of total limb occlusion pressure during baseline assessment PD-related medication change in the month prior to enrollment
Sites / Locations
- University of ColoradoRecruiting
Arms of the Study
Arm 1
Experimental
Low-load resistance training with blood flow restriction
Exercises will target bilateral 1) knee extensor, 2) ankle plantarflexor, and 3) elbow extensor muscles. Exercises will be dosed based on 1RM and individualized for each participant from a standardized exercise set. Progression will be based on 1) body position (supine, seated, standing), and 2) degree of resistance. Dosing will be re-assessed every 2 weeks and progressed as tolerated. Resistance will be provided by the Shuttle Mini-Press (Shuttle Systems), a portable resistance trainer that allows for precise dosing but is also adaptable to people with mobility limitations.