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Melodic Intonation Therapy for Tone Language Speakers

Primary Purpose

Dementia, Speech Therapy

Status
Suspended
Phase
Not Applicable
Locations
Hong Kong
Study Type
Interventional
Intervention
Melodic Intonation Therapy (MIT)
Sponsored by
The Hong Kong Polytechnic University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Dementia focused on measuring Melodic Intonation Therapy, Music, Tone language

Eligibility Criteria

50 Years - 100 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Early to moderate stage dementia patient
  • Normal hearing (hearing aid accepted)
  • Non-fluent speech (max. score of fluency in Cantonese Aphasia Battery spontaneous speech subtest = 6/10)

Exclusion Criteria:

  • Non-native Cantonese speaker
  • Illiterate
  • Aphasic patients
  • Subjects who receive other speech therapy during study

Sites / Locations

  • Elderly homes

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

MIT group

Control group

Arm Description

Subjects will receive the developed Melodic Intonation Therapy.

Subjects will not receive any intervention.

Outcomes

Primary Outcome Measures

Change in Aphasia Quotient (AQ) in Cantonese Aphasia Battery
Two subtests of the Cantonese Aphasia Battery (auditory comprehension & spontaneous speech) will be executed. Higher AQ means better performance in the respective areas. The minimum of AQ in each subtest is 0, and the maximum is 20.

Secondary Outcome Measures

Change in latency and accuracy in picture naming task
In the computerized picture naming task, subjects are asked to name the objects they see in 52 pictures, within 5000 ms per picture. Visual stimuli of the task are black and white line-drawings. Responses are all recorded for analysis.
Change in performance of semantic fluency task
In the computerized semantic fluency task, subjects are given 5 categories (e.g. animals) and asked to name as many members of the categories (e.g. cat, dog) as possible. For each category, they have one minute to respond. All the responses are recorded for analysis.

Full Information

First Posted
January 3, 2020
Last Updated
April 8, 2020
Sponsor
The Hong Kong Polytechnic University
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1. Study Identification

Unique Protocol Identification Number
NCT04221386
Brief Title
Melodic Intonation Therapy for Tone Language Speakers
Official Title
Melodic Intonation Therapy for Tone Language Speakers
Study Type
Interventional

2. Study Status

Record Verification Date
December 2019
Overall Recruitment Status
Suspended
Why Stopped
Coronavirus
Study Start Date
August 1, 2020 (Anticipated)
Primary Completion Date
December 31, 2020 (Anticipated)
Study Completion Date
February 28, 2021 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
The Hong Kong Polytechnic University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
One of the traditional therapies for restoring the ability of speech in aphasic patients is Melodic Intonation Therapy (MIT), in which everyday phrases are taught in a singing-like manner. The suggested mechanism for speech recovery is that because of the sharing of brain resources for language and music, the regions normally reserved for singing can be trained to help compensate the speech functions originally subserved by the damaged regions. However, this therapy has primarily been applied to speakers of non-tone languages, in which prosodic features carry a more important role than pitch features in conveying meanings. It remains unknown whether MIT will be equally applicable for speakers of tone languages, in which pitch features likely play a more important role. Another uncertainty concerns whether the efficacy of MIT can be extended to patients with expressive speech impairment due to dementia. This pilot study aims to find out the efficacy of MIT for speech-impaired dementia patients in different verbal tasks. The results of this study will provide preliminary empirical evidence to establish the utility of MIT for Cantonese speakers in Hong Kong.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Dementia, Speech Therapy
Keywords
Melodic Intonation Therapy, Music, Tone language

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare Provider
Allocation
Randomized
Enrollment
40 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
MIT group
Arm Type
Experimental
Arm Description
Subjects will receive the developed Melodic Intonation Therapy.
Arm Title
Control group
Arm Type
No Intervention
Arm Description
Subjects will not receive any intervention.
Intervention Type
Behavioral
Intervention Name(s)
Melodic Intonation Therapy (MIT)
Intervention Description
Subjects will receive at least 6 MIT sessions in group of 3-5 subjects. In the sessions, experimenter will sing songs with the subjects. Songs used in the intervention are familiar to elderly and are rewritten and embedded with everyday phrases and vocabularies. The whole intervention will span 3-4 weeks.
Primary Outcome Measure Information:
Title
Change in Aphasia Quotient (AQ) in Cantonese Aphasia Battery
Description
Two subtests of the Cantonese Aphasia Battery (auditory comprehension & spontaneous speech) will be executed. Higher AQ means better performance in the respective areas. The minimum of AQ in each subtest is 0, and the maximum is 20.
Time Frame
within a week after procedure
Secondary Outcome Measure Information:
Title
Change in latency and accuracy in picture naming task
Description
In the computerized picture naming task, subjects are asked to name the objects they see in 52 pictures, within 5000 ms per picture. Visual stimuli of the task are black and white line-drawings. Responses are all recorded for analysis.
Time Frame
within a week after procedure
Title
Change in performance of semantic fluency task
Description
In the computerized semantic fluency task, subjects are given 5 categories (e.g. animals) and asked to name as many members of the categories (e.g. cat, dog) as possible. For each category, they have one minute to respond. All the responses are recorded for analysis.
Time Frame
within a week after procedure

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
100 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Early to moderate stage dementia patient Normal hearing (hearing aid accepted) Non-fluent speech (max. score of fluency in Cantonese Aphasia Battery spontaneous speech subtest = 6/10) Exclusion Criteria: Non-native Cantonese speaker Illiterate Aphasic patients Subjects who receive other speech therapy during study
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
William Shi Yuan Wang, Ph.D.
Organizational Affiliation
The Hong Kong Polytechnic University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Elderly homes
City
Hong Kong
Country
Hong Kong

12. IPD Sharing Statement

Plan to Share IPD
No
IPD Sharing Plan Description
All the data collected in screening, pre- and post-assessment will not be shared with other researchers.
Citations:
PubMed Identifier
4717723
Citation
Albert ML, Sparks RW, Helm NA. Melodic intonation therapy for aphasia. Arch Neurol. 1973 Aug;29(2):130-1. doi: 10.1001/archneur.1973.00490260074018. No abstract available.
Results Reference
background
PubMed Identifier
4452250
Citation
Sparks R, Helm N, Albert M. Aphasia rehabilitation resulting from melodic intonation therapy. Cortex. 1974 Dec;10(4):303-16. doi: 10.1016/s0010-9452(74)80024-9. No abstract available.
Results Reference
background
PubMed Identifier
30312779
Citation
Sarkamo T, Sihvonen AJ. Golden oldies and silver brains: Deficits, preservation, learning, and rehabilitation effects of music in ageing-related neurological disorders. Cortex. 2018 Dec;109:104-123. doi: 10.1016/j.cortex.2018.08.034. Epub 2018 Sep 19.
Results Reference
result

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Melodic Intonation Therapy for Tone Language Speakers

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