Memory for Action in Neurological Patients (EMBODIMENT)
Alzheimer Disease, Parkinson Disease
About this trial
This is an interventional basic science trial for Alzheimer Disease focused on measuring Alzheimer, Parkinson, Action memory
Eligibility Criteria
Inclusion Criteria for 3 arms:
- Patient affiliated to a social security system
- Age between 55 and 80 years
- Normal vision and hearing or successfully corrected
- French mother tongue
- Signature of consent by participants
Specific criteria for inclusion of MA patients:
- Probable AD diagnosis made by a neurologist (McKhann et al., 2011)
- Mini-Mental State Examination (MMSE): score > 22
- Stable treatment for two months minimum.
Specific criteria for inclusion of PD patients:
- PD diagnosed by a neurologist (Postuma et al., 2015)
- Stable treatment for two months minimum.
- Mini-Mental State Examination (MMSE): score > 27
- Under dopaminergic treatment
Exclusion Criteria for 3 arms:
- Other neurological or psychiatric history
- Anxiety and depressive symptoms (assessed by the scale of depression-anxiety HAD; Zigmond & Snaith, 1983)
- Inability to communicate
- Significant impairment of judgment
- Delusional or psychotic state
Criteria common for non-inclusion of AD and PD patients:
- Other neurological or psychiatric history
- Anxiety and depressive symptoms (assessed by the scale of depression-anxiety HAD; Zigmond & Snaith, 1983)
- Inability to communicate
- Significant impairment of judgment
- Delusional or psychotic state
Criteria for non-inclusion of PD patients:
- Motor fluctuations
Criteria for non-inclusion of controls:
- Psychiatric or neurological disorders
- Anxiety and depressive symptoms (assessed by the scale of depression-anxiety HAD; Zigmond & Snaith, 1983)
Sites / Locations
- CHU de Saint-Etienne
- Hcl - Cm2R
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Sham Comparator
patients with Alzheimer disease
patients with Parkinson disease
healthy controls
Behavioral: Cognitive tests Only patients with Alzheimer disease will be included in this arm. Patients will perform different tasks : MMSE, (Folstein et al., 1975), HAD (Hospital Anxiety and Depression Scale; Zigmond & Snaith, 1983), a cognitive assessment (the 5 words test, Dubois et al., 2002; Trail Making test, Godefroy et al., 2008; BREF, Dubois et Pillon, 2000; Assessment of apraxia, Mahieux-Laurent, 2009) + the experimental task (verbal learning and action learning).
Behavioral: Cognitive tests Only patients with Parkinson disease will be included in this arm. Patients will perform different tasks : MMSE, (Folstein et al., 1975), HAD (Hospital Anxiety and Depression Scale; Zigmond & Snaith, 1983), a cognitive assessment (the 5 words test, Dubois et al., 2002; Trail Making test, Godefroy et al., 2008; BREF, Dubois et Pillon, 2000; Assessment of apraxia, Mahieux-Laurent, 2009) + the experimental task (verbal learning and action learning).
Behavioral: Cognitive tests Only patients with healthy controls will be included in this arm. Controls will perform different tasks : MMSE, (Folstein et al., 1975), HAD (Hospital Anxiety and Depression Scale; Zigmond & Snaith, 1983), a cognitive assessment (the 5 words test, Dubois et al., 2002; Trail Making test, Godefroy et al., 2008; BREF, Dubois et Pillon, 2000; Assessment of apraxia, Mahieux-Laurent, 2009) + the experimental task (verbal learning and action learning).