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Metabolic Fate Modifications of Saturated Fats After an Overfeeding (SURNUT)

Primary Purpose

Obesity, Lipid Metabolism, Inflammation

Status
Completed
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Hyperlipidic overfeeding
Sponsored by
Centre de Recherche en Nutrition Humaine Rhone-Alpe
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an interventional basic science trial for Obesity focused on measuring overfeeding, stable isotopes, lipoprotein metabolism, lipid oxidation, fat distribution, gene expression, endotoxemia, mass spectrometry/gas chromatography

Eligibility Criteria

18 Years - 55 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • 18 to 55 years old
  • BMI 18 to 30 kg/m²
  • Stable physical activity
  • Safety subject during medical consultation

Exclusion Criteria:

  • Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases)
  • Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones)
  • Eating disorder
  • Intensive sportive activity
  • Subjects who Smoke
  • Claustrophobic subjects

Sites / Locations

  • Centre de recherche en nutrition humaine Rhone-Alpes

Outcomes

Primary Outcome Measures

Post prandial partitioning of exogenous lipids

Secondary Outcome Measures

Genes expression in adipose and muscle tissues

Full Information

First Posted
May 20, 2009
Last Updated
June 22, 2011
Sponsor
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Collaborators
Institut National de la Santé Et de la Recherche Médicale, France
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1. Study Identification

Unique Protocol Identification Number
NCT00905892
Brief Title
Metabolic Fate Modifications of Saturated Fats After an Overfeeding
Acronym
SURNUT
Official Title
Metabolic Fate Modifications of Saturated Fats After an Overfeeding
Study Type
Interventional

2. Study Status

Record Verification Date
June 2011
Overall Recruitment Status
Completed
Study Start Date
September 2005 (undefined)
Primary Completion Date
December 2009 (Actual)
Study Completion Date
March 2010 (Actual)

3. Sponsor/Collaborators

Name of the Sponsor
Centre de Recherche en Nutrition Humaine Rhone-Alpe
Collaborators
Institut National de la Santé Et de la Recherche Médicale, France

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding. The method is based on the incorporation of a stable isotopic tracer (d31_palmitic acid, d31_C16) in lipoprotein triglycerides (TG-CHYLOMICRON and TG-VLDL) and in free fatty acids (FFA).
Detailed Description
Healthy overweight and lean young men are subjected to an overfeeding during 56 days which corresponds to a supplement of 761 Kcal/day. During two exploration days (before : D0 et after : D56 overfeeding) they have ingested a breakfast with tracer (d31_palmitic acid, d31_C16, 20mg/kg) and blood and urine samples were collected every hour of each exploration day. The enrichment in deuterium was measured by gas chromatography-organic mass spectrometry (GC-OMS) in palmitic acid pool of lipid fractions.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Obesity, Lipid Metabolism, Inflammation
Keywords
overfeeding, stable isotopes, lipoprotein metabolism, lipid oxidation, fat distribution, gene expression, endotoxemia, mass spectrometry/gas chromatography

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
40 (Anticipated)

8. Arms, Groups, and Interventions

Intervention Type
Dietary Supplement
Intervention Name(s)
Hyperlipidic overfeeding
Intervention Description
100g per day of cheese + 40g per day of almonds + 20g per day of butter
Primary Outcome Measure Information:
Title
Post prandial partitioning of exogenous lipids
Time Frame
Before and after overfeeding
Secondary Outcome Measure Information:
Title
Genes expression in adipose and muscle tissues
Time Frame
Before and after overfeeding

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: 18 to 55 years old BMI 18 to 30 kg/m² Stable physical activity Safety subject during medical consultation Exclusion Criteria: Medical or surgical history which may affect energy expenditure (renal -cardiovascular -hepatic- endocrine-inflammatory diseases) Drug use that could affect energy expenditure (steroids, nicotine substitutes, thyroid hormones) Eating disorder Intensive sportive activity Subjects who Smoke Claustrophobic subjects
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Martine Laville, PhD, MD
Organizational Affiliation
Centre de Recherche en Nutrition Humaine Rhône-Alpes
Official's Role
Study Director
Facility Information:
Facility Name
Centre de recherche en nutrition humaine Rhone-Alpes
City
Pierre-Bénite
ZIP/Postal Code
69495
Country
France

12. IPD Sharing Statement

Citations:
PubMed Identifier
30260393
Citation
Segrestin B, Moreno-Navarrete JM, Seyssel K, Alligier M, Meugnier E, Nazare JA, Vidal H, Fernandez-Real JM, Laville M. Adipose Tissue Expansion by Overfeeding Healthy Men Alters Iron Gene Expression. J Clin Endocrinol Metab. 2019 Mar 1;104(3):688-696. doi: 10.1210/jc.2018-01169.
Results Reference
derived
PubMed Identifier
24684464
Citation
Seyssel K, Alligier M, Meugnier E, Chanseaume E, Loizon E, Canto C, Disse E, Lambert-Porcheron S, Brozek J, Blond E, Rieusset J, Morio B, Laville M, Vidal H. Regulation of energy metabolism and mitochondrial function in skeletal muscle during lipid overfeeding in healthy men. J Clin Endocrinol Metab. 2014 Jul;99(7):E1254-62. doi: 10.1210/jc.2013-4379. Epub 2014 Mar 31.
Results Reference
derived
PubMed Identifier
22162470
Citation
Alligier M, Meugnier E, Debard C, Lambert-Porcheron S, Chanseaume E, Sothier M, Loizon E, Hssain AA, Brozek J, Scoazec JY, Morio B, Vidal H, Laville M. Subcutaneous adipose tissue remodeling during the initial phase of weight gain induced by overfeeding in humans. J Clin Endocrinol Metab. 2012 Feb;97(2):E183-92. doi: 10.1210/jc.2011-2314. Epub 2011 Dec 7.
Results Reference
derived

Learn more about this trial

Metabolic Fate Modifications of Saturated Fats After an Overfeeding

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