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Metabolic Study of Concentric and Eccentric Muscle Training

Primary Purpose

Lipid Metabolism, Insulin Resistance, Inflammation

Status

Completed

Phase

Not Applicable

Locations

Austria

Study Type

Interventional

Intervention

physical training

About this trial

This is an interventional educational/counseling/training trial for Lipid Metabolism focused on measuring exercise, lipid metabolism, lipoproteins, insulin resistance, inflammation

Eligibility Criteria

30 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

healthy men and women
age over 30 years

Exclusion Criteria:

previous systematic endurance training (≥3 times per week ≥30 min)
body mass index >30 kg/m2
heavy smoking (>20 cigarettes per day)
regular alcohol consumption >60g per day
established musculoskeletal disease
history of cardiovascular disease
diabetes mellitus
unwillingness to stay in the area for the whole study period

Sites / Locations

Vorarlberg Institute of Vascular Investigation and Treatment

Outcomes

Primary Outcome Measures

Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.

Secondary Outcome Measures

Metabolic and anti-inflammatory effects induced by concentric muscle exercise.

Full Information

NCT ID

NCT00386854

First Posted

October 10, 2006

Last Updated

October 10, 2006

Sponsor

Vorarlberg Institute for Vascular Investigation and Treatment

1. Study Identification

Unique Protocol Identification Number

NCT00386854

Brief Title

Metabolic Study of Concentric and Eccentric Muscle Training

Study Type

Interventional

2. Study Status

Record Verification Date

October 2006

Overall Recruitment Status

Completed

Study Start Date

April 2003 (undefined)

Primary Completion Date

undefined (undefined)

Study Completion Date

August 2003 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor

Vorarlberg Institute for Vascular Investigation and Treatment

4. Oversight

5. Study Description

Brief Summary

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.

Detailed Description

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans. Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Lipid Metabolism, Insulin Resistance, Inflammation

Keywords

exercise, lipid metabolism, lipoproteins, insulin resistance, inflammation

7. Study Design

Primary Purpose

Educational/Counseling/Training

Study Phase

Not Applicable

Interventional Study Model

Crossover Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

40 (false)

8. Arms, Groups, and Interventions

Intervention Type

Behavioral

Intervention Name(s)

physical training

Primary Outcome Measure Information:

Title

Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.

Secondary Outcome Measure Information:

Title

Metabolic and anti-inflammatory effects induced by concentric muscle exercise.

10. Eligibility

Sex

All

Minimum Age & Unit of Time

30 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: healthy men and women age over 30 years Exclusion Criteria: previous systematic endurance training (≥3 times per week ≥30 min) body mass index >30 kg/m2 heavy smoking (>20 cigarettes per day) regular alcohol consumption >60g per day established musculoskeletal disease history of cardiovascular disease diabetes mellitus unwillingness to stay in the area for the whole study period

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Heinz Drexel, MD

Organizational Affiliation

Vorarlberg Institut of Vascular Investigation and Treatment, Academic Teaching Hospital, Austria

Official's Role

Principal Investigator

Facility Information:

Facility Name

Vorarlberg Institute of Vascular Investigation and Treatment

City

Feldkirch

State/Province

Vorarlberg

ZIP/Postal Code

6807

Country

Austria

12. IPD Sharing Statement

Citations:

PubMed Identifier

34267272

Citation

Drexel H, Mader A, Saely CH, Tautermann G, Dopheide JF, Vonbank A. Downhill hiking improves low-grade inflammation, triglycerides, body weight and glucose tolerance. Sci Rep. 2021 Jul 15;11(1):14503. doi: 10.1038/s41598-021-93879-1.

Results Reference

derived

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Metabolic Study of Concentric and Eccentric Muscle Training

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