Open Label Study for the Use of Transcranial Ultrasound Treatment of Tremor
Tremor, Parkinson Disease, Essential Tremor
About this trial
This is an interventional treatment trial for Tremor
Eligibility Criteria
Inclusion Criteria:
In order for a subject to be considered for the Essential Tremor application of this study, the following criteria are required:
Subjective complaint of tremor assessed and validated by physician
Must be willing to comply with the study protocol
English Proficiency
At least 18 years of age
At most 90 years of age
In order for a subject to be considered for the Parkinson's Disease application of this study, the following criteria are required:
Diagnosis of Parkinson's Disease validated by physician
Must be willing to comply with the study protocol
English Proficiency
At least 18 years of age
At most 90 years of age
Exclusion Criteria:
In order for a subject to be considered for this study, he/she may NOT have any of the following:
Subjects not English proficient
Subjects unable to give informed consent
Subjects do not meet age requirements (18-90)
Subjects who would not be able to lay down without excessive movement in a calm environment sufficiently long enough to be able to achieve sleep
Pregnancy, women who may become pregnant or are breastfeeding
Women with child-bearing potential who are not willing to use a double-barrier birth control method
Males not willing to use a double-barrier birth control method with female sex partners with child-bearing potential
Advanced terminal illness
Any active cancer or chemotherapy
Any other neoplastic illness or illness characterized by neovascularity
Macular degeneration
Subjects with scalp rash or open wounds on the scalp (for example from treatment of squamous cell cancer)
Sites / Locations
- Neurological Associates of West Los AngelesRecruiting
Arms of the Study
Arm 1
Experimental
Experimental
Participants will undergo ten to thirty minutes of transcranial ultrasound treatment. The sanitation device will be aimed at the hypothalamus. Targeting will include reference to scalp fiducials based on the obtained MRI; confirmation of target accuracy will either be obtained by Doppler waveform confirmation or optical tracking technology which co-registers patient neuroimaging with real space.