Physical Exercise And Cognitive Engagement Outcomes for Mild Neurocognitive Disorder (PEACEOFMND)
Mild Cognitive Impairment, Memory Disorders, Mild Dementia
About this trial
This is an interventional treatment trial for Mild Cognitive Impairment
Eligibility Criteria
For the patients diagnosed with MCI:
Inclusion Criteria:
- Written informed consent for participation. Patient also needs to sign a legally authorized representative (LAR) addendum should MCI patient become incapacitated
- A diagnosis of amnestic MCI (single domain or multi-domain)
- A Clinical Dementia Rating scale score of 0 or 0.5
- At least 50.
- Either not taking or stable on nootropic(s) and/or pain medication for at least 3 months.
- Fluent in English.
- A score of at least 25 on the Telephone Interview for Cognitive Status for Memory.
Exclusion Criteria:
- MRI contraindications (e.g., ferrous metal in the body, claustrophobia, pregnancy)
- Physical impairments, language comprehension deficits, or significant hearing disturbances that would limit ability to perform tasks or participation in the intervention.
For the care partners:
Inclusion Criteria:
- Written informed consent for participation.
- At least 21 years of age.
- A score of at least 32 on the Telephone Interview for Cognitive Status for Memory.
- Partner has at least twice-weekly contact with the participant.
Exclusion Criteria:
1. Physical impairments, language comprehension deficits, or significant hearing disturbances that would limit ability to perform tasks or participation in the intervention.
Sites / Locations
- University of Florida
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
Computerized brain fitness training
Yoga
Wellness Education
Will receive a 10 day intervention program (over 2 weeks) consisting of Computer Brain Fitness Training, Calendar Training and Support Group. After the initial two week intervention, there will be an extended period during which participants will continue the computerized brain fitness for another 24 weeks.Participants are encouraged to do at least two hours per week.
Will receive a 10 day intervention program (over 2 weeks) consisting of Yoga, Calendar Training, and Support Group. After the initial two week intervention, there will be an extended period during which participants will continue yoga for 24 weeks. Participants assigned to the yoga intervention will continue to meet with their group and their yoga instructor for one hour per week and will be expected to do at least an additional hour of yoga by themselves every week.
Will receive a 10 day intervention program (over 2 weeks) consisting of Wellness Education, Calendar Training and Support Group.