Physiology, Imaging and Modeling of Essential Tremor
Essential Tremor, Parkinson Disease, Dystonia
About this trial
This is an interventional treatment trial for Essential Tremor focused on measuring Deep Brain Stimulation (DBS), ventralis intermedius nucleus (VIN), implantable pulse generator (IPG), Diffusion Tensor Imaging (DTI)
Eligibility Criteria
Inclusion Criteria:
- Existing unilateral or bilateral VIN DBS for ET, non-demented (MMSE>24), and must have a documented suboptimal tremor suppression on two successive visits (compared to the baseline post-operative improvement at 6 months following ET DBS surgery). For bilateral cases, the most affected tremor side will be studied.
Exclusion Criteria:
- No diagnosis of Essential Tremor
Sites / Locations
- UF Health at the University of FloridaRecruiting
- McKnight Brain Institute--Fixel Center for Neurological Diseases
Arms of the Study
Arm 1
Experimental
Patients with Essential Tremor
Patients with chronically implanted DBS devices for ET who experience progressive worsening of tremor symptoms over time. The DBS implantable pulse generator (IPG) will be loaded with a temporary custom firmware to allow implementation of active biphasic pulse stimulation. The following random conditions will be applied: (1) Home Settings; (2) VIN Biphasic; (3) Stimulator Off. A 30-minute washout period will be applied between each of the random conditions. Therefore, each patient will serve as their own control.