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Physiology of Weakness in Movement Disorders

Primary Purpose

Movement Disorders

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Movement Disorders focused on measuring Movement-Related Potential, Electroencephalogram, Psychogenic Movement Disorders, Psychogenic Movement Disorder, Healthy Volunteer, HV

Eligibility Criteria

18 Years - 80 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

INCLUSION CRITERIA: Both patients and healthy volunteers will be between age 18 and 80. Patients will be evaluated in the Human Motor Control Clinic at NINDS. The definite diagnosis of the disease may not be completely established at the time of recording. Patients have clear and reproducible symptoms of give way weakness of either upper or lower extremities. Patients have to be able to resist against the examiner for at least two seconds before giving way. Healthy volunteers are right handed adults without history of neurological disease or severe head trauma. EXCLUSION CRITERIA: Subjects (patients or volunteers) who cannot understand the instructions and consent forms of the protocol will be excluded. Subjects who cannot follow the instruction during the entire recording for whatever reason will be excluded. Patients with a documented organic central nervous system lesion may be excluded from the study. This will be discussed in detail for each individual subject at the Human Motor Control Clinic.

Sites / Locations

  • National Institutes of Health Clinical Center, 9000 Rockville Pike

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
March 24, 2006
Last Updated
June 30, 2017
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
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1. Study Identification

Unique Protocol Identification Number
NCT00307346
Brief Title
Physiology of Weakness in Movement Disorders
Official Title
Physiology of Weakness With Movement Disorders
Study Type
Observational

2. Study Status

Record Verification Date
January 25, 2011
Overall Recruitment Status
Completed
Study Start Date
March 23, 2006 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
January 25, 2011 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)

4. Oversight

5. Study Description

Brief Summary
This study will compare electroencephalograph (EEG) recordings in healthy volunteers and in people with movement disorders to examine brain activity associated with the weakness. EEG records the electrical activity of the brain ("brain waves"). Healthy volunteers and patients with arm or leg weakness who are between 18 and 80 years of age may be eligible for this study. Healthy subjects are screened with a medical history, physical and neurological examinations, and a questionnaire. They must be right-handed and never have had a neurological disease or head trauma. All participants have an EEG. An elastic cap with electrodes is placed on the subject's scalp to record the brain's electrical activity. During the EEG, subjects are required to resist against a force with their arm, elbow, shoulder or leg for as long as they can. Several recordings are done with short breaks between them.
Detailed Description
Objective Give way weakness is a symptom often associated with psychogenic etiology, but its neurophysiological basis is poorly understood. Our objective in this study is to identify the cerebral mechanism of give way weakness. Study population We will study 6 patients with give way weakness and 6 healthy volunteers all age 18 years old or older. Design In this study, patients will try to resist against the examiner's force and subsequently give way. Electroencephalography (EEG) will be recorded while this maneuver is performed repeatedly. Outcome measures Movement-related cortical potential (MRCP) analysis will be performed on the data and its amplitude (in volts) and latency (in seconds) in each individual patient will be described in contrast to the data obtained from healthy volunteers.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Movement Disorders
Keywords
Movement-Related Potential, Electroencephalogram, Psychogenic Movement Disorders, Psychogenic Movement Disorder, Healthy Volunteer, HV

7. Study Design

Enrollment
6 (Actual)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
INCLUSION CRITERIA: Both patients and healthy volunteers will be between age 18 and 80. Patients will be evaluated in the Human Motor Control Clinic at NINDS. The definite diagnosis of the disease may not be completely established at the time of recording. Patients have clear and reproducible symptoms of give way weakness of either upper or lower extremities. Patients have to be able to resist against the examiner for at least two seconds before giving way. Healthy volunteers are right handed adults without history of neurological disease or severe head trauma. EXCLUSION CRITERIA: Subjects (patients or volunteers) who cannot understand the instructions and consent forms of the protocol will be excluded. Subjects who cannot follow the instruction during the entire recording for whatever reason will be excluded. Patients with a documented organic central nervous system lesion may be excluded from the study. This will be discussed in detail for each individual subject at the Human Motor Control Clinic.
Facility Information:
Facility Name
National Institutes of Health Clinical Center, 9000 Rockville Pike
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
7489662
Citation
Terada K, Ikeda A, Nagamine T, Shibasaki H. Movement-related cortical potentials associated with voluntary muscle relaxation. Electroencephalogr Clin Neurophysiol. 1995 Nov;95(5):335-45. doi: 10.1016/0013-4694(95)00098-j.
Results Reference
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PubMed Identifier
10363761
Citation
Terada K, Ikeda A, Yazawa S, Nagamine T, Shibasaki H. Movement-related cortical potentials associated with voluntary relaxation of foot muscles. Clin Neurophysiol. 1999 Mar;110(3):397-403. doi: 10.1016/s1388-2457(98)00017-0.
Results Reference
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PubMed Identifier
10212312
Citation
Toma K, Honda M, Hanakawa T, Okada T, Fukuyama H, Ikeda A, Nishizawa S, Konishi J, Shibasaki H. Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study. J Neurosci. 1999 May 1;19(9):3527-34. doi: 10.1523/JNEUROSCI.19-09-03527.1999.
Results Reference
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Physiology of Weakness in Movement Disorders

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