Prenatal Probiotic Intervention
Childhood Obesity, Maternal Obesity During Childbirth, Insulin Resistance
About this trial
This is an interventional prevention trial for Childhood Obesity focused on measuring Obesity, Inflammation, Pregnancy, Programming
Eligibility Criteria
Inclusion Criteria:
- BMI ≥ 30
- ≥ 18 years of age
- Singleton pregnancy
- Less than 12 weeks of gestation
- Less than 1 serving of yoghurt with live cultures or cultured milk per week
- Conceived without assisted fertility treatments
Exclusion Criteria:
• Women with pre-existing medical conditions (e.g., diabetes, hypertension, thyroid disorders, heart disease or immune disorders) as determined by the PI to affect the outcomes of interest
- Immunosuppressed women
- Women taking medications during pregnancy known to affect fetal growth (i.e., thyroid hormone, glucocorticoids, insulin, oral hypoglycemic agents)
- Women who are using recreational drugs, tobacco or alcohol during their pregnancy
- Milk intolerance or allergy
- Consuming probiotic supplements
Sites / Locations
- Arkansas Children's Nutrition Center
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Probiotics
Placebo
Each probiotic capsule contains 180 mg of a standardized white to light beige fine powder consisting of freeze-dried cultures. Specifically, Bifidobacterium BB-12® and Lactobacillus rhamnosus LGG® (50%:50%). This product has a minimum potency of 6.5 billion (6.5E+9) CFU (ColonyForming Units) per capsule. Other ingredients in the powder are: microcrystalline cellulose, maltodextrin, silicon dioxide and magnesium stearate. Participants in this group will take one daily capsule orally starting at the time of recruitment (gestation week 12) and until delivery.
Participants in this group will take one capsule containing microcrystalline cellulose, maltodextrin, silicon dioxide and magnesium stearate (all ingredients listed in the probiotic capsules except the culture) . Participants in this group will take one daily capsule orally starting at the time of recruitment (gestation week 12) and until delivery.