Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity
Apnea
About this trial
This is an interventional treatment trial for Apnea focused on measuring caffeine, apnea, preterm infant
Eligibility Criteria
Inclusion Criteria:
- Infants eligible for this study will be newborn infants ≤ 32 weeks with or without a diagnosis of apnea .
Exclusion Criteria:
- Newborn infants with gestational age > 32 weeks.
- Newborn infants with congenital malformations and chromosomal anomalies.
- Newborn infants with apnea of other causes .
Sites / Locations
- Mansoura University Children Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Prophylactic caffeine citrate
Therapeutic caffeine citrate
Prophylactic caffeine (group1) will be defined as caffeine prescribed for preterm infant within the first 72 hours of life prior to manifest apnea . patients will be randomly assigned to receive caffeine in loading dose 20 mg/kg (equivalent for 10 mg/kg caffeine base) and maintenance dose 10 mg/kg/day (equivalent for 5 mg/kg caffeine base) .
Therapeutic caffeine ( group 2 ) will be defined as caffeine prescribed for manifest apnea within or after the first 72 hours of life . patients will be randomly assigned to receive caffeine in loading dose 20 mg/kg (equivalent for 10 mg/kg caffeine base) and maintenance dose 10 mg/kg/day (equivalent for 5 mg/kg caffeine base).