RATe Control in Atrial Fibrillation (RATAF)
Atrial Fibrillation
About this trial
This is an interventional treatment trial for Atrial Fibrillation focused on measuring Atrial fibrillation
Eligibility Criteria
Inclusion Criteria: Persistent or permanent atrial fibrillation with ventricular rate > 80/min at rest and/or > 100/min average at daytime. Male or female, age > 18. Exclusion Criteria: Hypersensitivity or contraindication to metoprolol, verapamil, diltiazem or carvedilol. Coronary heart disease or heart failure Systolic blood pressure < 100 mmHg AV-conduction disturbance Severe hepatic or renal dysfunction Thyrotoxicosis Ongoing treatment with Digitalis Pregnancy or lactation
Sites / Locations
- Vestre Viken Hospital Trust, Baerum Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Metoprolol
Diltiazem
Verapamil
Carvedilol
Treatment with Metoprolol 100 mg x 1 for three weeks
Treatment with Diltiazem 360 mg x 1 for three weeks
Treatment with Verapamil 240 mg x 1 for three weeks
Treatment with Carvedilol 25 mg x 1 for three weeks