Back to resultsResistance Exercise Training at Different Intensities
Primary Purpose
Sarcopenia, Frailty, Aging
Status
Completed
Phase
Not Applicable
Locations
United Kingdom
Study Type
Interventional
Intervention
Low Load Resistance exercise
High Load Resistance exercise
Sponsored by
About this trial
This is an interventional treatment trial for Sarcopenia
Eligibility Criteria
Inclusion Criteria:
- Over age of 65 years
Exclusion Criteria:
- Current participation in an exercise programme
- Exercise deemed unsafe by clinical team
Sites / Locations
- GRI Clinical Research Facility
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
Low load
High load
Arm Description
Training at 30-40% one-repetition maximum (1RM)
Training at 65-75% one-repetition maximum (1RM)
Outcomes
Primary Outcome Measures
Muscle strength
Knee extensor maximal torque during an isometric MVC
Secondary Outcome Measures
Vastus lateralis muscle thickness
Measured via ultrasound
Muscle strength
Knee flexor maximal torque during an isometric MVC
One-repetition maximum
leg extension, leg curl, leg press and calf press
Biomechanics during walking and stair climbing
Motion analysis
Short performance physical battery test
SPPB - balance, walking pace and chair rise
Quality of life measure
EQ-5D-5L questionnaire
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04053920
Brief Title
Resistance Exercise Training at Different Intensities
Official Title
Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study
Study Type
Interventional
2. Study Status
Record Verification Date
March 2020
Overall Recruitment Status
Completed
Study Start Date
March 1, 2018 (Actual)
Primary Completion Date
December 18, 2019 (Actual)
Study Completion Date
December 18, 2019 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Glasgow
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial population that includes both healthy and frail older people.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sarcopenia, Frailty, Aging
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
60 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Low load
Arm Type
Experimental
Arm Description
Training at 30-40% one-repetition maximum (1RM)
Arm Title
High load
Arm Type
Experimental
Arm Description
Training at 65-75% one-repetition maximum (1RM)
Intervention Type
Behavioral
Intervention Name(s)
Low Load Resistance exercise
Intervention Description
leg extension, leg press, leg curl and calf press
Intervention Type
Behavioral
Intervention Name(s)
High Load Resistance exercise
Intervention Description
leg extension, leg press, leg curl and calf press
Primary Outcome Measure Information:
Title
Muscle strength
Description
Knee extensor maximal torque during an isometric MVC
Time Frame
Change from baseline to 8 weeks
Secondary Outcome Measure Information:
Title
Vastus lateralis muscle thickness
Description
Measured via ultrasound
Time Frame
Change from baseline to 8 weeks
Title
Muscle strength
Description
Knee flexor maximal torque during an isometric MVC
Time Frame
Change from baseline to 8 weeks
Title
One-repetition maximum
Description
leg extension, leg curl, leg press and calf press
Time Frame
Change from baseline to 8 weeks
Title
Biomechanics during walking and stair climbing
Description
Motion analysis
Time Frame
Change from baseline to 8 weeks
Title
Short performance physical battery test
Description
SPPB - balance, walking pace and chair rise
Time Frame
Change from baseline to 8 weeks
Title
Quality of life measure
Description
EQ-5D-5L questionnaire
Time Frame
Change from baseline to 8 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Over age of 65 years
Exclusion Criteria:
Current participation in an exercise programme
Exercise deemed unsafe by clinical team
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Stuart Gray
Organizational Affiliation
University of Glasgow
Official's Role
Principal Investigator
Facility Information:
Facility Name
GRI Clinical Research Facility
City
Glasgow
ZIP/Postal Code
G12 8TA
Country
United Kingdom
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
Resistance Exercise Training at Different Intensities
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