Safety and Effectiveness of tPA in Intra-abdominal Abscesses
Abscess
About this trial
This is an interventional treatment trial for Abscess focused on measuring tissue plasminogen activator, intraabdominal, abscess, percutaneous drainage
Eligibility Criteria
Inclusion Criteria:
- Intrabdominal abscess
Exclusion Criteria:
- Hypersensitivity to tPA
- Recent stroke
- Uncontrolled htn
- Recent major hemorrhage
- Pregnancy
Sites / Locations
- University Health Network
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Tissue Plasminogen Activator
Instillation of Normal Saline
tPA administered by drainage tube into abscess, allowed to dwell for one hour and then drained into drainage bag. Dose of tPA administered to be determined by the volume of drainage immediately post drain insertion. This intervention is done on day 0, 1 and 2.
Insertion of abdominal drainage tube to drain intra-abdominal abscess. Normal Saline administered immediately post drain insertion. Normal Saline (10 cc) allowed to dwell for one hour, then allowed to drain into drainage bag.