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Salt Sensitivity, Cardiovascular and Metabolic Disease

Primary Purpose

Cardiovascular Diseases, Heart Diseases, Hypertension

Status
Completed
Phase
Locations
Study Type
Observational
Intervention
Sponsored by
Indiana University
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Cardiovascular Diseases

Eligibility Criteria

undefined - 100 Years (Child, Adult, Older Adult)MaleDoes not accept healthy volunteers

No eligibility criteria

Sites / Locations

    Outcomes

    Primary Outcome Measures

    Secondary Outcome Measures

    Full Information

    First Posted
    May 25, 2000
    Last Updated
    December 28, 2015
    Sponsor
    Indiana University
    Collaborators
    National Heart, Lung, and Blood Institute (NHLBI)
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    1. Study Identification

    Unique Protocol Identification Number
    NCT00005489
    Brief Title
    Salt Sensitivity, Cardiovascular and Metabolic Disease
    Study Type
    Observational

    2. Study Status

    Record Verification Date
    December 2015
    Overall Recruitment Status
    Completed
    Study Start Date
    January 1998 (undefined)
    Primary Completion Date
    undefined (undefined)
    Study Completion Date
    December 2001 (undefined)

    3. Sponsor/Collaborators

    Name of the Sponsor
    Indiana University
    Collaborators
    National Heart, Lung, and Blood Institute (NHLBI)

    4. Oversight

    5. Study Description

    Brief Summary
    To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.
    Detailed Description
    DESIGN NARRATIVE: Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Cardiovascular Diseases, Heart Diseases, Hypertension, Angina Pectoris, Cerebrovascular Accident, Myocardial Infarction, Diabetes Mellitus, Heart Failure, Congestive, Heart Failure

    7. Study Design

    10. Eligibility

    Sex
    Male
    Maximum Age & Unit of Time
    100 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    No eligibility criteria
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Myron Weinberger
    Organizational Affiliation
    Indiana University-Purdue University

    12. IPD Sharing Statement

    Citations:
    PubMed Identifier
    11230313
    Citation
    Weinberger MH, Fineberg NS, Fineberg SE, Weinberger M. Salt sensitivity, pulse pressure, and death in normal and hypertensive humans. Hypertension. 2001 Feb;37(2 Pt 2):429-32. doi: 10.1161/01.hyp.37.2.429.
    Results Reference
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    PubMed Identifier
    11864792
    Citation
    Weinberger M, Weinberger MH, Fineberg N, Fineberg SE, Wagner U. Long-term follow-up of participants in clinical studies. J Clin Epidemiol. 2002 Mar;55(3):230-4. doi: 10.1016/s0895-4356(01)00437-1.
    Results Reference
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    PubMed Identifier
    12160189
    Citation
    Weinberger MH, Fineberg NS, Fineberg SE. The influence of blood pressure and carbohydrate tolerance on vascular compliance in humans. Am J Hypertens. 2002 Aug;15(8):678-82. doi: 10.1016/s0895-7061(02)02955-2.
    Results Reference
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    PubMed Identifier
    12147930
    Citation
    Weinberger MH. Salt sensitivity is associated with an increased mortality in both normal and hypertensive humans. J Clin Hypertens (Greenwich). 2002 Jul-Aug;4(4):274-6. doi: 10.1111/j.1524-6175.2002.00924.x.
    Results Reference
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    PubMed Identifier
    11991223
    Citation
    Weinberger MH, Fineberg NS, Fineberg SE. Effects of age, race, gender, blood pressure, and estrogen on arterial compliance. Am J Hypertens. 2002 Apr;15(4 Pt 1):358-63. doi: 10.1016/s0895-7061(02)02261-6.
    Results Reference
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    Salt Sensitivity, Cardiovascular and Metabolic Disease

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