Spectrometry (MRM) Versus I 125 Radioimmunoassay (RIA) for Quantification of Orexin-A of Patients With Hypersomnolence (MRM-OREX)
Narcolepsy, Idiopathic Hypersomnia, Cataplexy
About this trial
This is an interventional diagnostic trial for Narcolepsy focused on measuring orexin/hypocretin, sleepiness
Eligibility Criteria
Inclusion Criteria: Age ≥ 8 years Complaint of hypersomnolence and suspected central hypersomnolence Benefiting from a standardised assessment: clinical, biological and neurophysiological Lumbar puncture necessary for the assessment Sufficient cerebrospinal fluid taken for biological analysis (at least 1 ml) Signed informed consent Exclusion Criteria: Contraindication to lumbar puncture Secondary hypersomnolence Refusal to participate in the study or refusal of the lumbar puncture Adult protected by law, or subject deprived of liberty, by judicial or administrative decision or patient under guardianship or curatorship Subject not affiliated to the French social security system Pregnant or breastfeeding woman