Study of Aerobic Training for People Receiving Chemotherapy for Breast Cancer

Inclusion Criteria: Aged ≥18 years Female Diagnosed with primary breast cancer as defined by one of the following: Histological confirmation As per standard of care imaging Scheduled to receive neoadjuvant/adjuvant chemotherapy Performing ≤90 minutes of moderate- and/or strenuous-intensity exercise per week, as evaluated by self-report Willingness to comply with all study-related procedures Able to achieve an acceptable peak baseline CPET, as defined by any of the following criteria: Achieving a plateau in oxygen consumption, concurrent with an increase in power output; A respiratory exchange ratio ≥ 1.10; Attainment of maximal predicted heart rate (HRmax) (i.e., within 10 bpm of age-predicted HRmax [HRmax = 220-Age[years]); Volitional exhaustion, as measured by a rating of perceived exertion (RPE) ≥ 18 on the BORG scale. Exclusion Criteria: Enrollment onto any other interventional investigational study, except interventions determined by the PI not to confound study outcomes Receiving treatment for any other diagnosis of invasive cancer Distant metastatic malignancy of any kind Mental impairment leading to inability to cooperate Any of the following contraindications to cardiopulmonary exercise testing: i. Acute myocardial infarction within 3-5 days of any planned study procedures; ii. Unstable angina; iii. Uncontrolled arrhythmia causing symptoms or hemodynamic compromise; iv. Recurrent syncope; v. Active endocarditis; vi. Acute myocarditis or pericarditis; vii. Symptomatic severe aortic stenosis; viii. Uncontrolled heart failure; ix. Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures; x. Thrombosis of lower extremities; xi. Suspected dissecting aneurysm; xii. Uncontrolled asthma; xiii. Pulmonary edema; xiv. Respiratory failure; xv. Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis) xvi. Room air desaturation at rest ≤ 85% Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation