Systematic Multi-domain Alzheimer's Risk Reduction Trial (SMARRT)
Dementia, Alzheimer Disease
About this trial
This is an interventional prevention trial for Dementia
Eligibility Criteria
Inclusion Criteria:
- 70-89 Years of Age
- Fluent in the English Language
- Low-normal performance on a brief telephone cognitive screen, measured using the Cognitive Abilities Screening Instruments (CASI). Low-normal scores are defined as 26-29.
- Has at least two additional risk factors that will be targeted by the intervention.
Exclusion Criteria:
- Residing in a skilled nursing or rehabilitation facility
- Receiving palliative care or hospice services
- Charlson comorbidity index score of greater than 5
- Bipolar illness or schizophrenia
- Current alcohol or drug use disorder
- Receiving chronic opioid therapy
- Parkinson's disease, amyotrophic lateral sclerosis, or multiple sclerosis
- Severe visual or hearing impairment
- Requests not to be contacted or not to have their medical record reviewed for research
- Prior evidence of dementia
Sites / Locations
- Kaiser Permanente Washington Health Research Institute
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
SMARRT Intervention
Health Education Intervention
The SMARRT intervention team will use a standardized procedure to develop an individualized Alzheimer's risk profile for each participant randomized to the SMARRT intervention arm. Participants will then meet in-person with an interventionist to review their risk profile and develop an initial personalized risk reduction action plan. For the few participants enrolled during COVID, initial interventionist visits were conducted by phone. Targeted areas will include: increasing physical, mental and social activities; quitting smoking; healthy diet; controlling cardiovascular risk factors (diabetes, hypertension), including avoiding hypoglycemia in people with diabetes; reducing depressive symptoms; improving sleep; and decreasing use of potentially harmful medications.
Participants in the Health Education arm will be mailed general information that will address factors that will be targeted in the SMARRT intervention, including physical, mental and social engagement; management of cardiovascular risk factors; quitting smoking, healthy diet; depression; sleep; and contraindicated medications. HE participants will not be provided with personalized information about their risk of Alzheimer's and dementia.