Back to resultsThe Connection Between Areas in the Brain of Blind Patients
Primary Purpose
Blindness, Brain Mapping, Healthy
Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
O15
Cadwell rTMS
Sponsored by
About this trial
This is an observational trial for Blindness focused on measuring Plasticity, Magnetic Stimulation, PET, Blind, Braille, Transcranial Magnetic Stimulation
Eligibility Criteria
INCLUSION CRITERIA: Subjects with late blindness. Subjects with early blindness. Sighted volunteers. Age between 18 and 65 years. EXCLUSION CRITERIA: Subjects with personal or family history of seizures or other neurological or demyelinating disorders. Pregnant women tested after urine pregnancy test. Subjects with metal in the cranium except mouth. Subjects with intracardiac lines and implanted medication pumps. Subjects with increased intracranial pressure as evaluated by clinical means. Subjects with cardiac pacemakers. Intake or neuroleptics. Subjects with blindness secondary to degenerative CNS diseases.
Sites / Locations
- National Institute of Neurological Disorders and Stroke (NINDS)
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT00001926
First Posted
November 3, 1999
Last Updated
March 3, 2008
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
1. Study Identification
Unique Protocol Identification Number
NCT00001926
Brief Title
The Connection Between Areas in the Brain of Blind Patients
Official Title
Connectivity of Occipital and Somatosensory Cortical Areas in Blind Subjects
Study Type
Observational
2. Study Status
Record Verification Date
November 2003
Overall Recruitment Status
Completed
Study Start Date
April 1999 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
November 2003 (undefined)
3. Sponsor/Collaborators
Name of the Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
4. Oversight
5. Study Description
Brief Summary
The purpose of this study is to test the belief that specific areas of the brain are connected differently in blind patients than patients with sight. In addition, the study will examine the different anatomical connections between brain areas of patients who became blind early in life versus patients who became blind later.
Detailed Description
The purpose of this protocol is to test the hypothesis that the anatomical connectivity of occipital and somatosensory areas in early blind subjects differs from that in subjects who became blind later in life and from that in sighted volunteers.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Blindness, Brain Mapping, Healthy
Keywords
Plasticity, Magnetic Stimulation, PET, Blind, Braille, Transcranial Magnetic Stimulation
7. Study Design
Enrollment
45 (false)
8. Arms, Groups, and Interventions
Intervention Type
Drug
Intervention Name(s)
O15
Intervention Type
Device
Intervention Name(s)
Cadwell rTMS
10. Eligibility
Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
INCLUSION CRITERIA:
Subjects with late blindness.
Subjects with early blindness.
Sighted volunteers.
Age between 18 and 65 years.
EXCLUSION CRITERIA:
Subjects with personal or family history of seizures or other neurological or demyelinating disorders.
Pregnant women tested after urine pregnancy test.
Subjects with metal in the cranium except mouth.
Subjects with intracardiac lines and implanted medication pumps.
Subjects with increased intracranial pressure as evaluated by clinical means.
Subjects with cardiac pacemakers.
Intake or neuroleptics.
Subjects with blindness secondary to degenerative CNS diseases.
Facility Information:
Facility Name
National Institute of Neurological Disorders and Stroke (NINDS)
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States
12. IPD Sharing Statement
Citations:
PubMed Identifier
2004259
Citation
Cohen LG, Bandinelli S, Findley TW, Hallett M. Motor reorganization after upper limb amputation in man. A study with focal magnetic stimulation. Brain. 1991 Feb;114 ( Pt 1B):615-27. doi: 10.1093/brain/114.1.615.
Results Reference
background
PubMed Identifier
1371745
Citation
Fuhr P, Cohen LG, Dang N, Findley TW, Haghighi S, Oro J, Hallett M. Physiological analysis of motor reorganization following lower limb amputation. Electroencephalogr Clin Neurophysiol. 1992 Feb;85(1):53-60. doi: 10.1016/0168-5597(92)90102-h.
Results Reference
background
PubMed Identifier
7884476
Citation
Kew JJ, Ridding MC, Rothwell JC, Passingham RE, Leigh PN, Sooriakumaran S, Frackowiak RS, Brooks DJ. Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation. J Neurophysiol. 1994 Nov;72(5):2517-24. doi: 10.1152/jn.1994.72.5.2517.
Results Reference
background
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The Connection Between Areas in the Brain of Blind Patients
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