The ECLA/PHRI Intervention in the Community Trial (EPIC)
Hypertension
About this trial
This is an interventional prevention trial for Hypertension focused on measuring Sodium Chloride, Dietary
Eligibility Criteria
Inclusion Criteria: Subjects ≥ 18 and ≤ 90 years old will be included, with no specific clinical conditions from households that meets the following criteria: The household must be composed of at least 2 individuals At least 1 of the individuals included must be over 40 years of age The household must be located in Rosario department, Santa Fe province, Argentina Exclusion Criteria: Households will be excluded if a any household member has a at least one of the following contraindication to the salt substitute used in the trial: use of a potassium-sparing diuretic use of a potassium supplement known history of hyperkalemia use of salt reduced in sodium and enriched in potassium by medical indication do not consume any type of salt for medical indication known primary or secondary hyperaldosteronism known severe kidney disease (routine biochemical measurement of kidney function will not be performed in household members not included in the study). Pregnancy or lactation Evidence of hyperkalemia and/or a creatinine clearance (calculated through the CKD-EPI formula <30 ml/min/1.73m2) in baseline blood laboratory. For those participants who consent to be tested, blood sample will be used. For those participant who has a laboratory test performed with those biomarkers in the past 6 months those results will be considered Households in which any of the study participants consume more than 50% of their meals prepared outside their home will also be excluded.
Sites / Locations
- IIC-Instituto de Investigaciones ClínicasRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
No Intervention
Experimental
Experimental
Control
Salt substitute 1
Salt substitute 2
regular salt (99% sodium chloride)
Salt substitute 1 is a potassium-enriched salt substitute composed of 66% potassium chloride and 33% sodium chloride
Salt substitute 2 is a potassium-enriched salt substitute composed of 33% potassium chloride and 66% sodium chloride