The Effect of Brown Adipose Tissue Activation on Insulin Sensitivity in Humans
Insulin Sensitivity, Obesity
About this trial
This is an interventional basic science trial for Insulin Sensitivity focused on measuring Insulin sensitivity, Diabetes Prevention, Obesity, Brown adipose tissue
Eligibility Criteria
Inclusion Criteria:
- men or women
- 18-75 years old
- BMI 20-40 kg/m2
Exclusion Criteria:
- taking diabetes medications
- liver/renal/endocrine/heart disease
- obstructive disease of the gastrointestinal tract
- impaired gag reflex or swallowing disorder
- history of GI surgery or fenilization of esophagus
- GI hypomotility disorder
- cancer
- thyroid or hormone replacement treatment
- beta-blockers
- anabolic or corticosteroids the last 6 mo
- pregnant/lactating women
- individuals that are likely to need PET/CT in the near future for medical reasons
- bleeding disorders/ anemia
- positive hepatitis or HIV screening
- weight less than 36 kg
- pacemaker or other implanted electromedical device
- alcohol and drug abuse
- tobacco use
- impaired cognition
- asthma
- chronic obstructive pulmonary disease (COPD) or other reactive airway diseases
Sites / Locations
- University of Texas Medical Branch at Galveston
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Cold water consumption
Meal consumption
Cold exposure
Exercise
Subjects will participate in two trials as part of this protocol: a) cold water (4 °C) consumption and b) tepid (36 °C) water consumption
Subjects will participate in two trials as part of this protocol: a) High calorie meal consumption and two weeks later b) no meal consumption.
Participants will complete three studies: a) cold exposure study (above their individually determined shivering threshold ~ 16°C); b) Cold exposure plus 0.5mg/kg up to 40mg propranolol at the beginning of the metabolic study and again after 4-6 hrs; c) thermoneutral conditions (26 - 28°C).
Subjects between 18 and 35 years old will be asked to participate in two trials: a) Exercise, i.e. four times for 10 min- at 85% VO2max (maximal oxygen consumption). with 15-min breaks between each bout b) and two weeks later rest.