Back to resultsThe Effects of Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder
Primary Purpose
Attention Deficit Disorder With Hyperactivity, Psychophysiology
Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
Working memory training
perceptual training
Sponsored by
About this trial
This is an interventional treatment trial for Attention Deficit Disorder With Hyperactivity
Eligibility Criteria
Inclusion Criteria:
- ADHD diagnosed according to criteria specified in Diagnostic and statistical manual of mental disorders (DSM-5)
- aged between 8 and 10 years
- intelligence quotient > 80 (based on Test of Nonverbal Intelligence-Third Edition)
- had normal or corrected-to-normal vision
- right-handed
Exclusion Criteria:
- diagnosis of clinically significant oppositional defiant disorder, Autistic Spectrum Disorders, Asperger's syndrome or depression
- history of seizures
Sites / Locations
- Chang Gung University
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
Control
Experiment
Arm Description
ADHD group treated with visual-perceptual training
ADHD group treated with working memory training
Outcomes
Primary Outcome Measures
Automated Working Memory Assessment
Visuospatial working memory change after intervention measured by Automated Working Memory Assessment
Secondary Outcome Measures
Working memory index in Wechsler Intelligence Scale for Children-IV
Verbal working memory change after intervention measured by Working memory index in WISC-IV
Event-related potentials
Event-related potentials are measured brain response on effects of working memory training
Full Information
NCT ID
NCT02959528
First Posted
October 31, 2016
Last Updated
October 25, 2017
Sponsor
Chang Gung Memorial Hospital
1. Study Identification
Unique Protocol Identification Number
NCT02959528
Brief Title
The Effects of Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder
Official Title
The Effects of Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder
Study Type
Interventional
2. Study Status
Record Verification Date
October 2017
Overall Recruitment Status
Completed
Study Start Date
October 2015 (undefined)
Primary Completion Date
November 25, 2016 (Actual)
Study Completion Date
January 19, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Chang Gung Memorial Hospital
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Previous studies indicated that children with attention-deficit/hyperactivity disorder (ADHD) often suffer from deficits in executive function, such as attentional control, inhibition, and working memory. One of these executive functions, working memory, plays a critical role in academic performance and classroom behavior. Working memory is essential for performing complex cognitive tasks such as comprehension, learning, and reasoning. Several studies have shown that training of working memory has positive effects for ADHD and other cognitive disorder in children. However, transfer effects across studies appear to be variable and inconsistent. Event-related potentials can be a useful tool to gain insights into such mechanism. Therefore, the aim of the present study is to investigate both near and far transfer effects of N-back training in children with ADHD. In addition, the recording and analysis of event-related potentials will be adopted while children with ADHD perform the complex visuo-spatial and phonological working memory tasks.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Attention Deficit Disorder With Hyperactivity, Psychophysiology
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
40 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Control
Arm Type
Active Comparator
Arm Description
ADHD group treated with visual-perceptual training
Arm Title
Experiment
Arm Type
Experimental
Arm Description
ADHD group treated with working memory training
Intervention Type
Other
Intervention Name(s)
Working memory training
Intervention Description
n-back training program
Intervention Type
Other
Intervention Name(s)
perceptual training
Intervention Description
visual-perceptual training program
Primary Outcome Measure Information:
Title
Automated Working Memory Assessment
Description
Visuospatial working memory change after intervention measured by Automated Working Memory Assessment
Time Frame
6 weeks
Secondary Outcome Measure Information:
Title
Working memory index in Wechsler Intelligence Scale for Children-IV
Description
Verbal working memory change after intervention measured by Working memory index in WISC-IV
Time Frame
6 weeks
Title
Event-related potentials
Description
Event-related potentials are measured brain response on effects of working memory training
Time Frame
6 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
8 Years
Maximum Age & Unit of Time
10 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
ADHD diagnosed according to criteria specified in Diagnostic and statistical manual of mental disorders (DSM-5)
aged between 8 and 10 years
intelligence quotient > 80 (based on Test of Nonverbal Intelligence-Third Edition)
had normal or corrected-to-normal vision
right-handed
Exclusion Criteria:
diagnosis of clinically significant oppositional defiant disorder, Autistic Spectrum Disorders, Asperger's syndrome or depression
history of seizures
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
I-Hsuan Shen, PhD
Organizational Affiliation
Chang Gung University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Chang Gung University
City
Taoyuan City
Country
Taiwan
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
The Effects of Working Memory Training in Children With Attention-Deficit/Hyperactivity Disorder
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