The Physiological Effects of Pacing on Catheter Ablation Procedures to Treat Atrial Fibrillation (PEP AF)
Atrial Fibrillation
About this trial
This is an interventional diagnostic trial for Atrial Fibrillation focused on measuring catheter ablation, atrial fibrillation
Eligibility Criteria
Inclusion Criteria:
- Patients with AF scheduled for AF ablation with planned pulmonary vein isolation
- Presenting in normal sinus rhythm (NSR) prior to lesion delivery
Exclusion Criteria:
- Previous radiofrequency ablation
- Previous thoracotomy-type AF ablation (MAZE or similar technique)
- In AF prior to lesion delivery
- Evidence of left atrial scarring on voltage map
- Resting heart rate > 90 bpm
Sites / Locations
- New York University School of Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
CA 1st Half of lesion
CA 2nd Half of Lesion
During each of the 15 pre-specified lesions, pacing will be initiated at a 500ms cycle length from a catheter in the coronary sinus or right ventricle prior to the start of the lesion. Pacing will be stopped at the halfway point (e.g. after 10 seconds for a 20-second lesion and after 15 seconds for a 30-second lesion). In the event that Wenckebach behavior is noted, pacing will be adjusted to a 550ms cycle length. In the event that Wenckebach behavior persists, the cycle length will be adjusted to 600ms. In the event that Weckebach behavior continues, the pacing catheter will be moved to the right ventricle, which and pacing will be performed at a 500ms cycle length. If Wenckebach behavior still persists, the patient will be withdrawn from the study.
During each of the 15 pre-specified lesions, pacing will be stopped at the halfway point (e.g. after 10 seconds for a 20-second lesion and after 15 seconds for a 30-second lesion). In the event that Wenckebach behavior is noted, pacing will be adjusted to a 550ms cycle length. In the event that Wenckebach behavior persists, the cycle length will be adjusted to 600ms. In the event that Wenckebach behavior persists, the pacing catheter will be moved to the right ventricle and pacing will be performed at a 500ms cycle length. If Wenckebach behavior still persists, the patient will be withdrawn from the study.