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Thrombectomy In TANdem Occlusion (TITAN)

Primary Purpose

Carotid Artery Diseases, Thrombectomy, Tandem Occlusion

Status
Recruiting
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
Carotid Stenting
Procedural Aspirin
Dual dual antiplatelet therapy after 24-hours imaging follow-up
Intracranial thrombectomy
Sponsored by
Central Hospital, Nancy, France
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional other trial for Carotid Artery Diseases focused on measuring stroke, tandem occlusion, carotid stenting, thrombectomy

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  1. Subject aged ≥ 18 years
  2. Tandem occlusion at angiography, in connection with atheromatous plaque or dissection, defined with:

    • Proximal intracranial occlusion (ICA, M1 and/or M2) eligible for thrombectomy
    • Extracranial lesion of the internal carotid artery (stenosis ≥90% NASCET or complete occlusion).
  3. NIHSS Score ≥ 6
  4. ASPECTS Score ≥ 6 by scanner or MRI (DWI)
  5. Arterial puncture within 8 hours (after the first symptoms or last seen well)
  6. The patient or his or her representative has received information about the study organization and has signed and dated the informed consent form/ inclusion in emergency situation in accordance with Article L1122-1-3 of the Public Health Code.
  7. Person affiliated to or beneficiary of a social security plan
  8. Person undergone the medical examination adapted to research Subjects treated with prior intravenous thrombolysis are eligible for participation

Exclusion Criteria:

  1. Extracranial internal carotid artery stenosis < 90% (NASCET) on the first angiographic run
  2. Rankin score (mRS) > 2
  3. Contraindication to antiplatelet (Aspirin, Plavix), or thrombolytic therapy (Actilyse), or contrast agents, or endovascular products.
  4. Patient unable to present or be available for follow-up
  5. Patient's refusal to participate
  6. Woman of childbearing age without effective contraception
  7. Pregnant, parturient or breastfeeding woman
  8. Minor person (non emancipated)
  9. Adult person under legal protection (any form of public guardianship)
  10. Person deprived of liberty for judicial or administrative decision
  11. Person under psychiatric care according to articles L. 3212-1 and L. 3213-1 of the Public Health Code.

Sites / Locations

  • CHRU de NancyRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

Thrombectomy + Carotid Stenting

Thrombectomy alone

Arm Description

Intravenous thrombolysis will be administered if possible. Standard mechanical thrombectomy(MT) will be performed with a balloon Guide Catheter. MT technique will be left at the discretion of the operators. Concerning the cervical disease, emergent carotid stenting will be performed if the patient is randomized in the intervention arm. The order to treat (head first or neck first), and the choice of a previous angioplasty of the extracranial carotid artery lesion will be left to the interventionist discretion. An intravenous bolus of 250mg of Aspirin (up to Imaging 24H) will be given at the end of the procedure in case of absence of complication. Intravenous sedation or general anesthesia will be permitted.A second antiplatelet agent is used if a thrombus is formed : IV or nasogastric tube (choice by operator) A dual antiplatelet therapy is administered after 24H imaging follow-up excluding intracranial hemorrhagic complications (discretion of the local practice)

Endovascular procedure: Intracranial thrombectomy alone (carotid angioplasty may be performed)

Outcomes

Primary Outcome Measures

Change in Modified treatment in cerebral ischemia (mTICI) score AND National Institutes of Health Stroke Scale (NIHSS) score
Complete reperfusion rate at the end of angiography defined as a modified Thrombolysis in Cerebral Infarction (mTICI) 3 score and defined as an Improvement of the National Institutes of Health Stroke Scale (NIHSS) score ≥ 4 mTICI score : 0:no perfusion ; 1:penetration with minimal perfusion ; 2:partial perfusion ; 2a:partial filling of less than 1/2 of the vascular territory ; 2b:partial filling 50-99% of the vascular territory ; 3:complete perfusion . NIHSS : 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items.

Secondary Outcome Measures

Efficacy outcomes : Rate of reperfusion with change in Modified treatment in cerebral ischemia (mTICI) score
Complete reperfusion rate at the end of angiography defined as a modified Thrombolysis in Cerebral Infarction (mTICI) 3 score. mTICI score (0,1,2,2a,2b,3) : Grade 0 : no perfusion Grade 1 : penetration with minimal perfusion Grade 2 : partial perfusion Grade 2a : partial filling of less than 1/2 of the vascular territory Grade 2b : partial filling 50-99% of the vascular territory Grade 3 : complete perfusion
Efficacy outcomes : Change in National Institutes of Health Stroke Scale (NIHSS) score
NIHSS improvement ≥ 4 points at 24 (±6) hours (blinded assessment : core laboratories of 2 independent neuroradiologists). National Institutes of Health Stroke Scale (NIHSS) score. The NIHSS is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The single patient assessment requires less than 10 minutes to complete. The evaluation of stroke severity depends upon the ability of the observer to accurately and consistently assess the patient.
Efficacy outcomes : number of participants with delays of symptoms
- Delays of symptoms onset to groin puncture, groin puncture to clot contact, groin puncture to reperfusion, and symptoms onset to reperfusion
Efficacy outcomes : Number of passes
Number of intracranial thrombectomy passes to achieve final reperfusion
Efficacy outcomes : Infarct growth (volume)
Infarct growth difference between treatment and control groups expressed as difference in Alberta Stroke Program Early CT score (ASPECT scores) at 24 (±6) hours. ASPECT scores : A 10-point score to assess ischemic stroke in the territory of the middle cerebral artery on a brain scan without injection. Calculated on a CT without axial cross-sectional injection: No hypodensity = 1 point Score = 10: total absence of hypodensity Score = 0 : hypodensity of the entire middle cerebral artery (MCA)territory A score ≤7 = pejorative prognosis in terms of both residual disability and risk of haemorrhagic transformation
Efficacy outcomes : Type and dose of antiplatelet agents administered
Type and dose of antiplatelet agents administered during the procedure, at 24 (±6) hours, at discharge (5-7 days).
Efficacy outcomes : Rate of recurrent clinical ischemic event
Rate of recurrent clinical ischemic event at 90 (±15) days in the ipsilateral carotid territory
Efficacy outcomes : Rate of functional independence
- Rate of functional independence defined as a modified Rankin Scale (mRS) score 0-2 at 90 (±15 days) and 12 months (blind and independent evaluation) The Modified Rankin Score (mRS) is a 6 point disability scale with possible scores ranging from 0 to 5. A separate category of 6 is usually added for patients who expire. The Modified Rankin Score (mRS) is the most widely used outcome measure in stroke clinical trials. Standardized interviews to obtain a mRS score are recommended at 3 months (90 days) following hospital discharge.
Safety outcomes : Rate of procedural complications
Rate of procedural complications: vascular perforation, arterial dissection, embolization to new territory, access site complication requiring surgical repair or blood transfusion, intra-procedural mortality, and device failure
Safety outcomes : Rates of carotid stenosis and stent thrombosis
Rates of carotid stenosis and stent thrombosis at the end of the endovascular procedure
Safety outcomes : Rate of symptomatic and asymptomatic intracerebral hemorrhage
Rate of symptomatic and asymptomatic intracerebral hemorrhage at CT (Computerized Tomography) or MRI (Magnetic Resonance Imaging) at 24 hours (±6 hours) according to the Heidelberg classification (independent imaging core laboratory)
Safety outcomes : Rate of carotid stenosis and stent thrombosis
Rate of carotid stenosis (NASCET : North American Symptomatic Carotid Endarterectomy Trial Collaborators), and stent thrombosis at 24 (±6) hours on Computerized Tomography Angiography (CTA) or Magnetic Resonance Angiography (MRA)
Safety outcomes :Rate of secondary decompressive craniotomy
Rate of secondary decompressive craniotomy at discharge (5-7 days)
Safety outcomes : Rate of endarterectomy
Rate of endarterectomy at 90 (±15) days, and 12 (±1) months
Safety outcomes : Rate of mortality
Rate of mortality at 24 (±6) hours, 90 (±15) days, and 12 (±1) months
Cost effectiveness outcomes : value the additional cost of gaining additional clinical (NIHSS)
A cost-effectiveness analysis on secondary outcome criteria will be conducted to value the additional cost of gaining additional clinical benefit at 24 hours (NIHSS), and at 3 months (mRS), especially in terms of functional ability, using an incremental cost-effectiveness ratio. The result will be presented as cost per additional case of disability averted.
Cost effectiveness outcomes : value the additional cost of gaining additional clinical (mRS)
A cost-effectiveness analysis on secondary outcome criteria will be conducted to value the additional cost of gaining additional clinical benefit at 24 hours (NIHSS), and at 3 months (mRS), especially in terms of functional ability, using an incremental cost-effectiveness ratio. The result will be presented as cost per additional case of disability averted.
Cost effectiveness outcomes : cost of safety issues
Cost of safety issues will be considered. The time horizon will be at 3 months. The analysis will be conducted in the National Health Insurance System (NHIS) perspective. For this purpose, the investigators will classify each patient's stay in the appropriate Diagnosis-Related Group (DRG).
Cost effectiveness outcomes : a cost-utility analysis
in a perspective of generic comparison, a cost-utility analysis will be conducted by using quality of life scores collected at 12 months of the intervention. The objective is to estimate the cost by one quality-adjusted life year (QALY) gained.
Cost effectiveness outcomes : a budget impact analysis
a budget impact analysis will be performed. The objective is to estimate the total cost of adopting the combined approach of treatment at the national level and the expected number of disability cases averted.

Full Information

First Posted
May 29, 2019
Last Updated
September 15, 2023
Sponsor
Central Hospital, Nancy, France
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1. Study Identification

Unique Protocol Identification Number
NCT03978988
Brief Title
Thrombectomy In TANdem Occlusion
Acronym
TITAN
Official Title
Intracranial Thrombectomy and Extracranial Carotid Stenting Versus Intracranial Thrombectomy Alone In Acute Anterior Circulation Strokes With TANdem Occlusion : the Randomized Controlled TITAN Trial
Study Type
Interventional

2. Study Status

Record Verification Date
September 2023
Overall Recruitment Status
Recruiting
Study Start Date
April 29, 2020 (Actual)
Primary Completion Date
October 30, 2025 (Anticipated)
Study Completion Date
October 30, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Central Hospital, Nancy, France

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
Yes
Product Manufactured in and Exported from the U.S.
Yes
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Tandem occlusion is defined by an acute ischemic stroke (AIS) with concomitant steno-occlusive disease of the extra cranial carotid artery and concerned about 10% of AIS patients. Whereas endovascular treatment has shown its efficiency in AIS by large vessel occlusion (LVO), to date, there is no consensus on the endovascular management of the extra cranial carotid artery in tandem occlusion. Only few of them were included in previous randomized trials who evaluated mechanical thrombectomy and were often listed in the non-inclusion criteria. Therapeutic management of this population was not specifically addressed in recent trials. Endovascular management can be complex with the need of acute stenting of the extra cranial carotid lesion along with the potential need of antithrombotic therapy initiation, the benefit and the safety of stenting of the cervical lesion in acute phase of AIS have shown encouraging results but however remains to be assessed. The TITAN (Thrombectomy In TANdem lesion) trial aims to demonstrate the superiority of the combined use of intracranial thrombectomy and extracranial carotid stenting compared to intracranial thrombectomy alone on the complete reperfusion rate in patients with acute ischemic stroke due to tandem lesion.
Detailed Description
The TITAN trial is a prospective, randomized, multi center, controlled, open-label, blinded clinical trial. This academic trial designed to answer the question: "What is the best endovascular management of the extra cranial carotid artery lesion in tandem occlusion with LVO" Patients will be recruited at 13 comprehensive stroke centers in France, all of which regular conduct mechanical thrombectomy and carotid stenting. This study will enroll adults patients admitted with cerebral infarction of the anterior circulation, proven by computed tomography (CT) or magnetic resonance (MR) angiography, associated with tandem lesion, within 8 hours of symptoms onset, with a neurological deficit NIHSS > 5, and eligible to thrombectomy according to the recommendations of the French societies of neurovascular disease and neuroradiology (SFNR and SFNV). Tandem occlusion of the anterior circulation will be proven on digital subtraction angiography, defined as a proximal intracranial occlusion and an extracranial severe internal carotid artery (ICA) lesion (complete occlusion or stenosis ≥90% North American Symptomatic Carotid Endarterectomy Trial). Informed Consent according to the French laws will be sought from the patient if their level of consciousness is sufficient or from a relative. This study will operate using an emergency inclusion protocol due to the nature of the condition. After emergency inclusion procedure according to French regulations, eligible patients will be randomized in two balanced parallel groups to receive either combined treatment intracranial thrombectomy with carotid stenting or intracranial thrombectomy alone. Treatment and Intervention Intravenous thrombolysis will be administered if possible. Standard MT will be performed with a balloon Guide Catheter (BGC). MT technique (contact aspiration, stent retriever, or solumbra) will be left at the discretion of the operators. Concerning the cervical disease, emergent carotid stenting will be performed if the patient is randomized in the intervention arm. The order to treat (head first or neck first), and the choice of a previous angioplasty of the extracranial carotid artery lesion will be left to the interventionist discretion. An intravenous bolus of 250mg of Aspirin will be given at the end of the procedure in case of absence of complication. (Aspirin 250mg IV up to Imaging 24H).A second antiplatelet agent is used if a thrombus is formed : IV or nasogastric tube (choice by operator) Primary objective : To demonstrate the superiority of intracranial thrombectomy and extracranial carotid stenting compared to intracranial thrombectomy alone on the complete reperfusion (mTICI 3 at the end of the endovascular procedure) rate and on the rate of NIHSS ≥ 4 points improvement at 24 hours in AIS patients with a tandem occlusion of the anterior circulation. Secondary objectives : To assess the feasibility and the efficacy of the combined approach associating intracranial thrombectomy and extracranial carotid stenting compared to intracranial thrombectomy alone using a composite criterion (mTICI3 at the end of the endovascular procedure or NIHSS improvement ≥ 4 points at 24h). To compare the safety of intracranial thrombectomy and extracranial carotid stenting compared to intracranial thrombectomy alone. To evaluate the cost-effectiveness and cost-utility of the combined approach compared to intracranial thrombectomy alone. The Data and Safety Monitored Board (DSMB) will provide subject safety oversight and make recommendations to the Sponsor regarding continuing enrollment, modifying, or stopping the study early based upon a review of safety data and more specifically the comparative rates of symptomatic intracranial hemorrhage and, neurological worsening (NIHSS4 points increase), at D1, and mortality rates. They will take into account in their decision making and recommendations the rates of procedure-related and device-related events in the treatment group. DSMB meetings will be organized by call conference by the sponsor before the start of the study and every year until the end of the study. The members will also receive the results of interim analyses. Additional extraordinary meetings will be set if necessary. It will be constituted with two independent clinicians and one expert in methodology. Sample Size Estimates Prior data indicate that a reperfusion rate of 30% mTICI 3 was observed with mechanical thrombectomy in patients with tandem lesions. Assuming acute carotid stenting will bring a 15% gain, a sample size of 162 patients per group will allow to evidence such gain with a 80% power at a 5% type I error (PS v3.0). Allowing 5% loss to follow up leads to include 216 patients per group, i.e. 432 patients in total

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Carotid Artery Diseases, Thrombectomy, Tandem Occlusion, Stroke
Keywords
stroke, tandem occlusion, carotid stenting, thrombectomy

7. Study Design

Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
432 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Thrombectomy + Carotid Stenting
Arm Type
Experimental
Arm Description
Intravenous thrombolysis will be administered if possible. Standard mechanical thrombectomy(MT) will be performed with a balloon Guide Catheter. MT technique will be left at the discretion of the operators. Concerning the cervical disease, emergent carotid stenting will be performed if the patient is randomized in the intervention arm. The order to treat (head first or neck first), and the choice of a previous angioplasty of the extracranial carotid artery lesion will be left to the interventionist discretion. An intravenous bolus of 250mg of Aspirin (up to Imaging 24H) will be given at the end of the procedure in case of absence of complication. Intravenous sedation or general anesthesia will be permitted.A second antiplatelet agent is used if a thrombus is formed : IV or nasogastric tube (choice by operator) A dual antiplatelet therapy is administered after 24H imaging follow-up excluding intracranial hemorrhagic complications (discretion of the local practice)
Arm Title
Thrombectomy alone
Arm Type
No Intervention
Arm Description
Endovascular procedure: Intracranial thrombectomy alone (carotid angioplasty may be performed)
Intervention Type
Device
Intervention Name(s)
Carotid Stenting
Intervention Description
emergent carotid stenting will be performed if the patient is randomized in the intervention arm. The order to treat (head first or neck first), and the choice of a previous angioplasty of the extracranial carotid artery lesion will be left to the interventionist discretion.
Intervention Type
Drug
Intervention Name(s)
Procedural Aspirin
Intervention Description
After carotid stenting, an intravenous bolus of 250mg of Aspirin will be given at the end of the procedure in case of absence of complication.
Intervention Type
Drug
Intervention Name(s)
Dual dual antiplatelet therapy after 24-hours imaging follow-up
Intervention Description
A dual antiplatelet therapy is administered after 24-hours imaging follow-up excluding intracranial hemorrhagic complications (the type and the dose of the dual antiplatelet therapy are left to the discretion of the local practice)
Intervention Type
Procedure
Intervention Name(s)
Intracranial thrombectomy
Intervention Description
Intracranial thrombectomy is the endovascular procedure. In the experimental group, thrombectomy will be completed with a extracranial carotid stenting.
Primary Outcome Measure Information:
Title
Change in Modified treatment in cerebral ischemia (mTICI) score AND National Institutes of Health Stroke Scale (NIHSS) score
Description
Complete reperfusion rate at the end of angiography defined as a modified Thrombolysis in Cerebral Infarction (mTICI) 3 score and defined as an Improvement of the National Institutes of Health Stroke Scale (NIHSS) score ≥ 4 mTICI score : 0:no perfusion ; 1:penetration with minimal perfusion ; 2:partial perfusion ; 2a:partial filling of less than 1/2 of the vascular territory ; 2b:partial filling 50-99% of the vascular territory ; 3:complete perfusion . NIHSS : 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items.
Time Frame
at the end of angiography(mTICI score) , at 24 hours (NIHSS score)
Secondary Outcome Measure Information:
Title
Efficacy outcomes : Rate of reperfusion with change in Modified treatment in cerebral ischemia (mTICI) score
Description
Complete reperfusion rate at the end of angiography defined as a modified Thrombolysis in Cerebral Infarction (mTICI) 3 score. mTICI score (0,1,2,2a,2b,3) : Grade 0 : no perfusion Grade 1 : penetration with minimal perfusion Grade 2 : partial perfusion Grade 2a : partial filling of less than 1/2 of the vascular territory Grade 2b : partial filling 50-99% of the vascular territory Grade 3 : complete perfusion
Time Frame
at the end of the endovascular procedure
Title
Efficacy outcomes : Change in National Institutes of Health Stroke Scale (NIHSS) score
Description
NIHSS improvement ≥ 4 points at 24 (±6) hours (blinded assessment : core laboratories of 2 independent neuroradiologists). National Institutes of Health Stroke Scale (NIHSS) score. The NIHSS is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patent's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. The single patient assessment requires less than 10 minutes to complete. The evaluation of stroke severity depends upon the ability of the observer to accurately and consistently assess the patient.
Time Frame
at 24 hours (±6) hours
Title
Efficacy outcomes : number of participants with delays of symptoms
Description
- Delays of symptoms onset to groin puncture, groin puncture to clot contact, groin puncture to reperfusion, and symptoms onset to reperfusion
Time Frame
at the end of the endovascular procedure
Title
Efficacy outcomes : Number of passes
Description
Number of intracranial thrombectomy passes to achieve final reperfusion
Time Frame
at the end of the endovascular procedure
Title
Efficacy outcomes : Infarct growth (volume)
Description
Infarct growth difference between treatment and control groups expressed as difference in Alberta Stroke Program Early CT score (ASPECT scores) at 24 (±6) hours. ASPECT scores : A 10-point score to assess ischemic stroke in the territory of the middle cerebral artery on a brain scan without injection. Calculated on a CT without axial cross-sectional injection: No hypodensity = 1 point Score = 10: total absence of hypodensity Score = 0 : hypodensity of the entire middle cerebral artery (MCA)territory A score ≤7 = pejorative prognosis in terms of both residual disability and risk of haemorrhagic transformation
Time Frame
At 24hours (±6) hours
Title
Efficacy outcomes : Type and dose of antiplatelet agents administered
Description
Type and dose of antiplatelet agents administered during the procedure, at 24 (±6) hours, at discharge (5-7 days).
Time Frame
at 24 (±6) hours, at discharge (5-7 days)
Title
Efficacy outcomes : Rate of recurrent clinical ischemic event
Description
Rate of recurrent clinical ischemic event at 90 (±15) days in the ipsilateral carotid territory
Time Frame
at 90 days for rate of recurrent clinical ischemic event
Title
Efficacy outcomes : Rate of functional independence
Description
- Rate of functional independence defined as a modified Rankin Scale (mRS) score 0-2 at 90 (±15 days) and 12 months (blind and independent evaluation) The Modified Rankin Score (mRS) is a 6 point disability scale with possible scores ranging from 0 to 5. A separate category of 6 is usually added for patients who expire. The Modified Rankin Score (mRS) is the most widely used outcome measure in stroke clinical trials. Standardized interviews to obtain a mRS score are recommended at 3 months (90 days) following hospital discharge.
Time Frame
at 90 days and 12 months for mRS
Title
Safety outcomes : Rate of procedural complications
Description
Rate of procedural complications: vascular perforation, arterial dissection, embolization to new territory, access site complication requiring surgical repair or blood transfusion, intra-procedural mortality, and device failure
Time Frame
At the end of endovascular procedure
Title
Safety outcomes : Rates of carotid stenosis and stent thrombosis
Description
Rates of carotid stenosis and stent thrombosis at the end of the endovascular procedure
Time Frame
At the end of endovascular procedure
Title
Safety outcomes : Rate of symptomatic and asymptomatic intracerebral hemorrhage
Description
Rate of symptomatic and asymptomatic intracerebral hemorrhage at CT (Computerized Tomography) or MRI (Magnetic Resonance Imaging) at 24 hours (±6 hours) according to the Heidelberg classification (independent imaging core laboratory)
Time Frame
at 24 hours (±6 hours)
Title
Safety outcomes : Rate of carotid stenosis and stent thrombosis
Description
Rate of carotid stenosis (NASCET : North American Symptomatic Carotid Endarterectomy Trial Collaborators), and stent thrombosis at 24 (±6) hours on Computerized Tomography Angiography (CTA) or Magnetic Resonance Angiography (MRA)
Time Frame
at 24 (±6) hours
Title
Safety outcomes :Rate of secondary decompressive craniotomy
Description
Rate of secondary decompressive craniotomy at discharge (5-7 days)
Time Frame
at discharge (or 5-7 days)
Title
Safety outcomes : Rate of endarterectomy
Description
Rate of endarterectomy at 90 (±15) days, and 12 (±1) months
Time Frame
at 90 days and 12 (±1) months
Title
Safety outcomes : Rate of mortality
Description
Rate of mortality at 24 (±6) hours, 90 (±15) days, and 12 (±1) months
Time Frame
at 24 (±6) hours, 90 (±15) days, and 12 (±1) months
Title
Cost effectiveness outcomes : value the additional cost of gaining additional clinical (NIHSS)
Description
A cost-effectiveness analysis on secondary outcome criteria will be conducted to value the additional cost of gaining additional clinical benefit at 24 hours (NIHSS), and at 3 months (mRS), especially in terms of functional ability, using an incremental cost-effectiveness ratio. The result will be presented as cost per additional case of disability averted.
Time Frame
At 24 hours
Title
Cost effectiveness outcomes : value the additional cost of gaining additional clinical (mRS)
Description
A cost-effectiveness analysis on secondary outcome criteria will be conducted to value the additional cost of gaining additional clinical benefit at 24 hours (NIHSS), and at 3 months (mRS), especially in terms of functional ability, using an incremental cost-effectiveness ratio. The result will be presented as cost per additional case of disability averted.
Time Frame
at 3 months
Title
Cost effectiveness outcomes : cost of safety issues
Description
Cost of safety issues will be considered. The time horizon will be at 3 months. The analysis will be conducted in the National Health Insurance System (NHIS) perspective. For this purpose, the investigators will classify each patient's stay in the appropriate Diagnosis-Related Group (DRG).
Time Frame
At 3 months
Title
Cost effectiveness outcomes : a cost-utility analysis
Description
in a perspective of generic comparison, a cost-utility analysis will be conducted by using quality of life scores collected at 12 months of the intervention. The objective is to estimate the cost by one quality-adjusted life year (QALY) gained.
Time Frame
At 12 months
Title
Cost effectiveness outcomes : a budget impact analysis
Description
a budget impact analysis will be performed. The objective is to estimate the total cost of adopting the combined approach of treatment at the national level and the expected number of disability cases averted.
Time Frame
At 12 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Subject aged ≥ 18 years Tandem occlusion confirmed by MR angiography or CT-angiography or digital subtraction angiography of supra-aortic vessels, in connection with atheromatous plaque or dissection, defined with: Proximal intracranial occlusion (ICA, M1 and/or M2) eligible for thrombectomy Extracranial lesion of the internal carotid artery (stenosis ≥90% NASCET or complete occlusion). NIHSS Score ≥ 6 Arterial puncture performed : -> Within 8 hours (after the first symptoms or last seen well) with ASPECTS Score ≥5 by CT or MRI (DWI) OR -> Between 8 and 24 hours : If perfusion imaging performed: according to the DEFUSE3 trial criteria (ischemia ≤70 mL, ischemia-hypoperfusion ratio≥1.8, and hypoperfusion volume ≥15 mL) If perfusion imaging not performed: according to the DAWN trial criteria : Age ≥80 years with NIHSS ≥10 and ischemia ≤21 mL Age <80 years with NIHSS ≥10 and ischemia ≤31 mL Age <80 years with NIHSS ≥20 and ischemia ≤51 mL The patient or his or her representative has received information about the study organization and has signed and dated the informed consent form/ inclusion in emergency situation in accordance with Article L1122-1-3 of the Public Health Code. Person affiliated to or beneficiary of a social security plan Person undergone the medical examination adapted to research Subjects treated with prior intravenous thrombolysis are eligible for participation Exclusion Criteria: Extracranial internal carotid artery stenosis < 90% (NASCET) Rankin score (mRS) > 2 Contraindication to antiplatelet (Aspirin, Plavix), or thrombolytic therapy (Actilyse), or contrast agents, or endovascular products. Patient unable to present or be available for follow-up Patient's refusal to participate Woman of childbearing age without effective contraception Pregnant, parturient or breastfeeding woman Minor person (non emancipated) Adult person under legal protection (any form of public guardianship) Person deprived of liberty for judicial or administrative decision Person under psychiatric care according to articles L. 3212-1 and L. 3213-1 of the Public Health Code.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Benjamin GORY, PhD
Phone
+33383851501
Email
b.gory@chru-nancy.fr
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Benjamin GORY, PhD
Organizational Affiliation
CHRU de Nancy
Official's Role
Principal Investigator
Facility Information:
Facility Name
CHRU de Nancy
City
Vandoeuvre les Nancy
ZIP/Postal Code
54511
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Benjamin GORY

12. IPD Sharing Statement

Citations:
PubMed Identifier
32515696
Citation
Zhu F, Hossu G, Soudant M, Richard S, Achit H, Beguinet M, Costalat V, Arquizan C, Consoli A, Lapergue B, Rouchaud A, Macian-Montoro F, Biondi A, Moulin T, Marnat G, Sibon I, Paya C, Vannier S, Cognard C, Viguier A, Mazighi M, Obadia M, Hassen WB, Turc G, Clarencon F, Samson Y, Dumas-Duport B, Preterre C, Barbier C, Boulanger M, Janot K, Annan M, Bricout N, Henon H, Soize S, Moulin S, Labeyrie MA, Reiner P, Pop R, Wolff V, Ognard J, Timsit S, Reyre A, Perot C, Papagiannaki C, Triquenot-Bagan A, Bracard S, Anxionnat R, Derelle AL, Tonnelet R, Liao L, Schmitt E, Planel S, Guillemin F, Gory B. Effect of emergent carotid stenting during endovascular therapy for acute anterior circulation stroke patients with tandem occlusion: A multicenter, randomized, clinical trial (TITAN) protocol. Int J Stroke. 2021 Apr;16(3):342-348. doi: 10.1177/1747493020929948. Epub 2020 Jun 9.
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Thrombectomy In TANdem Occlusion

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