Time Course Adaptations Using Deuterated Creatine (D3Cr) Method

This is an interventional basic science trial for Sarcopenia focused on measuring muscle mass, muscle loss, Deuterated creatine (D3Cr) dilution, older adults, resistance training, physical function Read More

Inclusion Criteria:

• men and women aged 70 or greater
• at high risk for mobility disability based on lower extremity functional limitations measured by Short Physical Performance battery (SPPB) with a score ≤ 8 out of 12
• could safely participate in the resistance training intervention as determined by medical history and physical examination.
• willing to give informed consent to be randomized to either the resistance training group or successful aging heath education comparison group and willing to follow the study protocol

Exclusion Criteria:

• Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
• Myocardial infarction, major heart surgery, stroke, deep vein thrombosis, or pulmonary embolus in the past 6 months
• Lung disease requiring either oral or injected steroids, or the use of supplemental oxygen
• Short, portable mental status questionnaire with 3 or more errors
• Severe arthritis (either osteoarthritis or rheumatoid arthritis) that severely limits mobility
• Severe lower back or shoulder pain that can worsen with weight lifting exercises.
• Cancer requiring treatment in the past 1 year (Melanomas excluded)
• Any present or recent history of severe psychiatric illness including depression that might preclude providing informed consent, safe participation, or compliance (self-report and investigator judgement
• Development of chest pain or severe shortness of breath on the 400 m self-paced walk test
• Parkinson's disease or other serious neurological disorders; renal disease requiring dialysis; other illness of such severity that life expectancy is considered to be less than 12 months
• Current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder
• Current consumption of more than 14 alcoholic drinks per week
• Uncontrolled hypertension (systolic blood pressure > 200 mm Hg and/or diastolic blood pressure >110 mm Hg)
• Currently on testosterone, Dehydroepiandrosterone (DHEA), or anabolic steroids.
• Undergoing physical therapy involving the lower extremities
• Currently enrolled in another randomized trial involving a pharmaceutical or lifestyle intervention. Observational studies are permitted
• Participation in progressive resistance exercise regimen ( ≥1 day/week) within the previous 6 months prior to screening.
• Weight change (intentional or not) over the last 6 months of > 5% of body or plan to lose or gain weight during the study
• Any other cardiovascular, pulmonary, orthopedic, neurologic, or other conditions that in the opinion of the local clinician would preclude participation and successful completion of the protocol

Temporary Exclusion Criteria:

• Recent bacterial/viral infection (e.g. pneumonia) (< 2 weeks);
• Acute febrile illness in past 2 months;
• Severe hypertension, e.g., SBP > 200 mm Hg, DBP > 110 mm Hg
• Major surgery or fracture or hip/knee replacement (< 6 months);
• Hospitalization within the last 6 months ( Not ER visits)