Treatment of Functional Bowel Disorders
Irritable Bowel Syndrome, Constipation, Abdominal Pain
About this trial
This is an interventional treatment trial for Irritable Bowel Syndrome focused on measuring Functional bowel disorder, Irritable bowel syndrome, Painful constipation, Unspecified functional bowel disorder, Chronic functional abdominal pain, Cognitive-behavioral psychological treatment, IBS, CFAP
Eligibility Criteria
Inclusion Criteria: Literate, female patients aged 18-65. Symptoms present at least 2 days/week for greater than 6 months. Diagnosis of functional bowel disorder (to be subcategorized using ''Rome'' Criteria. Moderate (MFBD) or severe (SFBD) functional bowel disorder (FBD) based on the Functional Bowel Disorder Severity Index (FBDSI) developed in our pilot study. SFBD will be defined as a score of 110 and MFBD will be defined as a score between 36 and 110. Discontinuation of all antidepressant medications for at least 3 months. Use of acceptable method of birth control. Exclusion Criteria: Evidence of lactose intolerance to explain bowel symptoms. Heart disease. Cardiac arrhythmias. Severe psychiatric disorder (e.g., bipolar, suicide attempts). Previous use of desipramine. Glaucoma. Urinary retention. Pregnancy. Alcohol consumption 3oz/day that would preclude participation or prevent data assessment. Systemic gastrointestinal diseases or previous surgery that would interfere with the interpretation of symptoms or physiology. Bipolar disorder. Schizophrenia. Substance abuse/dependency. Previous use of desipramine.
Sites / Locations
- UNC Center for Functional GI Motility Disorders
- Centre for Addiction and Mental Health, Clark Site