Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness, Metabolic Flexibility and Glucose Tolerance in Obese Patients
Heart Failure With Normal Ejection Fraction, Obesity
About this trial
This is an interventional treatment trial for Heart Failure With Normal Ejection Fraction focused on measuring Obesity, Heart failure with preserved ejection fraction, HFpEF, unsaturated fatty acids, cardiorespiratory fitness, dietary intervention
Eligibility Criteria
Major Inclusion Criteria:
- Body Mass Index (BMI) ≥30 kg/m2 (obesity) or total body fat percentage >25% in men and >35% in women
- A confirmed clinical diagnosis of stable HF (New York Heart Association [NYHA] class II-III) on maximally tolerated heart failure (HF) optimal medical regimen (without major changes in the prior month)
- Left Ventricular Ejection Fraction (LVEF)>50% documented in the prior 12 months
Major Exclusion Criteria:
- Concomitant conditions or treatment which would affect completion or interpretation of the study (i.e.,physical inability to walk or run on treadmill);
- Significant ischemic heart disease, angina, uncontrolled arterial hypertension, atrial fibrillation, moderate to severe valvular disease, chronic pulmonary disease, anemia (Hemoglobin<10 g/dL)
- Electrocardiography (ECG) changes (ischemia or arrhythmias) that limit maximum exertion during cardiopulmonary exercise test
- Comorbidity limiting survival
- Stage IV-V kidney disease (estimated Glomerular Filtration Rate<30)
- Fluid overload
- Pregnancy
- Current use of unsaturated fatty acids (UFA) supplement (i.e., omega-3).
- Inability to give informed consent
Sites / Locations
- Virginia Commonwealth University
Arms of the Study
Arm 1
Experimental
Dietary Intervention
Dietary intervention aimed at increasing UFA consumption. The face-to-face intervention will be performed by a research nutritionist that reviews the dietary recall and provides a list of commonly available foods rich in unsaturated fatty acids (UFA) (monounsaturated [MUFA] and polyunsaturated fatty acids [PUFA]), together with individual instructions on how to integrate the recommended foods in the daily dietary pattern based on the dietary recall, and also to emphasize that the recommended food should be consumed as listed, and not as part of processed food (i.e., guacamole for avocado, hazelnut chocolate for nuts, pesto for olive oil, fish sticks for fatty fish). Extra-virgin olive oil or canola oil or nuts will be considered first choice for daily consumption of UFA-rich food, but a list of daily food substitutes will be also provided .