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Active clinical trials for "Aortic Aneurysm, Abdominal"

Results 41-50 of 419

Post-Market Study to Assess Outcomes of Patients Treated With AFX System Compared to Other EVAR...

Abdominal Aortic Aneurysm

The objective of this post-market trial is to evaluate Endologix AFX endovascular AAA system with anatomical fixation against other approved Endovascular systems with proximal fixation. Multiple U.S clinical centers will be involved in the trial to include a broad range of experience. Imaging data will be evaluated by an independent core lab.

Active8 enrollment criteria

DOTATATE PETMRI AAA Study

Abdominal Aortic Aneurysm

Abdominal Aortic Aneurysm (AAA) screening and an aging population have increased the prevalence of AAA diagnoses. Small AAAs (<5.5cm) are monitored with ultrasound. Large AAAs may rupture and this is usually fatal. Surgery is considered at a crude size threshold of 5.5cm when the annual rupture risk reaches 5%. AAA size is the only predictor of growth and rupture available but growth is non-linear and some small AAAs rupture. Thus, only 1 in 20 patients treated at 5.5cm will have benefited from rupture prevention in the year following surgery, and others may miss out on life-saving surgery. This study will develop an imaging tool PETMRI with radiotracer Ga- DOTATATE with high clinical utility, to improve prediction of aneurysm growth and risk.

Recruiting9 enrollment criteria

Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel...

Abdominal Aortic Aneurysm

The primary aim of this study is to establish the practicality of using two novel imaging modalities for the assessment of biomechanical properties of the aorta.

Recruiting7 enrollment criteria

NIH CCR2 AAA Study

Abdominal Aortic Aneurysm (AAA)No Abdominal Aortic Aneurysm (Non-AAA)

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease, which is typically asymptomatic until rupture, resulting in high mortality. AAAs are more prevalent in men over age 65, though rupture is disproportionately higher in women. Due to nonlinear and unpredictable aortic dilatation, it is challenging to predict the AAA rupture using clinical diagnostics based on morphology. No medical therapy is used clinically to treat AAA, and there is an unmet need for clinically translatable, molecular biomarkers of AAA disease activity for surveillance and patient-specific management. The goal of this proposal is to develop a new approach for the diagnosis and targeted therapy of AAA.

Recruiting13 enrollment criteria

Visceral (Kidney and Abdominal Organ) Function After Fenestrated and Branched Endovascular Aneurysm...

Aortic AneurysmAbdominal

The purpose of this study is to evaluate visceral function, after endovascular repair of thoracoabdominal aneurysms.

Enrolling by invitation37 enrollment criteria

Vector Velocity Imaging in AAA Patients

Abdominal AneurysmThrombus

The goal of this observational study is to perform an in vivo feasibility study using real time (3D) ultrasound based vector flow imaging in 10 AAA patients (5 with intraluminal thrombus and 5 without intraluminal thrombus). Furthermore, the investigators will investigate the added value of contrast microbubbles in these high framerate, plane wave ultrasound measurements. Included patients will undergo ultrasound scanning of their AAA, using multiple ultrasound sequences. Sequences will be tested with and without the addition of ultrasound contrast microbubbles.

Recruiting12 enrollment criteria

Endurant CHevAr New Indication Trial: ENCHANT

AAA - Abdominal Aortic Aneurysm

The purpose of the post-market study is to assess the clinical outcomes, safety, and performance of the Endurant Chimney Graft Technique (Endurant Stent Graft Systems used with a balloon-expandable covered stent graft) for treatment of juxtarenal aortic aneurysms with a short infrarenal neck in a real world setting.

Recruiting20 enrollment criteria

Clinical Outcomes of Patients Treated With Open Surgical Repair for Complex Aortic Aneurysms

Aortic AneurysmAbdominal

This is a prospective, non-randomized, single center, data collection study of patients treated with open surgical repair (OR) for complex aortic aneurysms (CAAs).

Recruiting7 enrollment criteria

Biomarker Profiling in Abdominal Aortic Aneurysm Patients

Abdominal Aortic Aneurysm

The BIOMArCS-AAA study aims to investigate the associations of (temporal patterns of) blood biomarkers with aneurysm growth in patients with abdominal aortic aneurysm (AAA), with particular attention to biomarkers that have demonstrated prognostic value for adverse disease outcomes in coronary artery disease and biomarkers for the main genetic pathways associated with AAA.

Recruiting12 enrollment criteria

Myocardial Injury in Treatment of AAA

Aortic AneurysmAbdominal2 more

Comparison of elective infrarenal aneurysm surgery with open and endovascular technique, respectively, for subclinical ischemic myocardial injury detectable with troponin T and/or 3-channel Holter ECG with ST analysis

Recruiting4 enrollment criteria
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