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Active clinical trials for "Angina Pectoris"

Results 1-10 of 454

PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion...

Coronary Artery DiseaseAngina Pectoris

The aim of the study is to compare post-interventional fractional flow reserve (FFR) value between optical coherence tomography(OCT)-guided and angiography-guided strategy for treatment of complex coronary lesion.

Recruiting27 enrollment criteria

Adenovirus Vascular Endothelial Growth Factor D (AdvVEGF-D) Therapy for Treatment of Refractory...

Refractory Angina PectorisGene Transfer1 more

The purpose of the study is to evaluate the safety and efficacy of catheter mediated endocardial adenovirus-mediated vascular endothelial growth factor-D (AdVEGF-D) regenerative gene transfer in patients with refractory angina to whom revascularisation cannot be performed.

Recruiting22 enrollment criteria

Use of the Neovasc Coronary Sinus Reducer System for the Treatment of Refractory Angina Pectoris...

Refractory Angina

The purpose of this study is to implant the Reducer in patients with the symptoms of refractory angina, that suffer from refractory angina who demonstrate reversible ischemia.

Recruiting15 enrollment criteria

Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina...

Unstable Angina

The purpose of this study is to evaluate differences in the pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite in patients who received ticagrelor followed with methoxyflurane versus ticagrelor followed with morphine or ticagrelor alone due to unstable angina pectoris

Recruiting27 enrollment criteria

Radiosurgery of Ganglion StELlatum In Patients With REFractory Angina Pectoris

Coronary Artery DiseaseAngina Pectoris1 more

The core hypothesis to be tested is that the radiosurgery of stellate ganglion (left one or both if left-sided without full relief of symptoms) is an effective therapy of refractory angina pectoris in patients with no other therapeutic options - proof of concept study.

Recruiting17 enrollment criteria

A Placebo-controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention for the...

Stable AnginaChronic Total Occlusion of Coronary Artery

ORBITA-CTO Pilot is a double blinded randomised placebo-controlled trial comparing the effects of chronic total occlusion percutaneous coronary intervention versus placebo on symptoms of angina in patients with background optimal medical therapy.

Recruiting22 enrollment criteria

Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries...

Refractory AnginaMicrovascular Angina3 more

To demonstrate the feasibility and efficacy of the CS Reducer for the treatment of patients with ischaemia and non-obstructed coronary arteries (INOCA) and coronary microvascular dysfunction (CMD) and through a nested mechanistic substudy investigate the physiological responses in the coronary microcirculation responsible for changes in myocardial perfusion.

Recruiting25 enrollment criteria

COSIMA: COronary SInus Reducer for the Treatment of Refractory Microvascular Angina

Coronary Microvascular DiseaseRefractory Angina

Patients with refractory microvascular angina fulfilling the predefined inclusion and exclusion criteria will be enrolled in this randomized trial. The primary objective is to investigate whether the proportion of patients reporting an improvement in Canadian Cardiovascular Society (CCS) angina class (≥2 classes) is different at six months after implantation of a Coronary Sinus Reducer followed by optimal medical therapy (OMT) compared to OMT alone.

Recruiting27 enrollment criteria

Invest-CTO PCI Trial

Chronic Total Occlusion of Coronary ArteryAngina Pectoris2 more

Following unsuccessful CTO crossing a CTO modification procedure is sometimes performed. CTO PCI registries where plaque modification has been performed in some patients, report this to be safe, and associated with higher success rates at subsequent attempts. It has never been investigated whether a planned investment procedure, with an intention that both the initial and staged completion PCI are of shorter duration, could improve safety and efficacy. The investigators hypothesize that A planned investment procedure in the treatment of CTOs will be associated with improved patient safety A planned investment procedure will be associated with improved cumulative procedure success rates A planned two stage procedure will be associated with improved patient experience

Recruiting13 enrollment criteria

Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive...

Coronary Microvascular DysfunctionMicrovascular Angina5 more

EXAMINE-CAD-DZHK22 is a prospective, randomized, double-blind, placebo-controlled, crossover trial investigating the efficacy of beta blocker (bisoprolol) and calcium channel blocker (diltiazem) therapy in symptomatic patients with non-obstructed coronary arteries according to coronary physiological testing results.

Recruiting32 enrollment criteria
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