PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion...
Coronary Artery DiseaseAngina PectorisThe aim of the study is to compare post-interventional fractional flow reserve (FFR) value between optical coherence tomography(OCT)-guided and angiography-guided strategy for treatment of complex coronary lesion.
Adenovirus Vascular Endothelial Growth Factor D (AdvVEGF-D) Therapy for Treatment of Refractory...
Refractory Angina PectorisGene Transfer1 moreThe purpose of the study is to evaluate the safety and efficacy of catheter mediated endocardial adenovirus-mediated vascular endothelial growth factor-D (AdVEGF-D) regenerative gene transfer in patients with refractory angina to whom revascularisation cannot be performed.
Use of the Neovasc Coronary Sinus Reducer System for the Treatment of Refractory Angina Pectoris...
Refractory AnginaThe purpose of this study is to implant the Reducer in patients with the symptoms of refractory angina, that suffer from refractory angina who demonstrate reversible ischemia.
Influence of METHoxyflurane on ANtiplatelet Effect of Ticagrelor in Patients With Unstable Angina...
Unstable AnginaThe purpose of this study is to evaluate differences in the pharmacokinetics and pharmacodynamics of ticagrelor and its active metabolite in patients who received ticagrelor followed with methoxyflurane versus ticagrelor followed with morphine or ticagrelor alone due to unstable angina pectoris
Radiosurgery of Ganglion StELlatum In Patients With REFractory Angina Pectoris
Coronary Artery DiseaseAngina Pectoris1 moreThe core hypothesis to be tested is that the radiosurgery of stellate ganglion (left one or both if left-sided without full relief of symptoms) is an effective therapy of refractory angina pectoris in patients with no other therapeutic options - proof of concept study.
A Placebo-controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention for the...
Stable AnginaChronic Total Occlusion of Coronary ArteryORBITA-CTO Pilot is a double blinded randomised placebo-controlled trial comparing the effects of chronic total occlusion percutaneous coronary intervention versus placebo on symptoms of angina in patients with background optimal medical therapy.
Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries...
Refractory AnginaMicrovascular Angina3 moreTo demonstrate the feasibility and efficacy of the CS Reducer for the treatment of patients with ischaemia and non-obstructed coronary arteries (INOCA) and coronary microvascular dysfunction (CMD) and through a nested mechanistic substudy investigate the physiological responses in the coronary microcirculation responsible for changes in myocardial perfusion.
COSIMA: COronary SInus Reducer for the Treatment of Refractory Microvascular Angina
Coronary Microvascular DiseaseRefractory AnginaPatients with refractory microvascular angina fulfilling the predefined inclusion and exclusion criteria will be enrolled in this randomized trial. The primary objective is to investigate whether the proportion of patients reporting an improvement in Canadian Cardiovascular Society (CCS) angina class (≥2 classes) is different at six months after implantation of a Coronary Sinus Reducer followed by optimal medical therapy (OMT) compared to OMT alone.
Invest-CTO PCI Trial
Chronic Total Occlusion of Coronary ArteryAngina Pectoris2 moreFollowing unsuccessful CTO crossing a CTO modification procedure is sometimes performed. CTO PCI registries where plaque modification has been performed in some patients, report this to be safe, and associated with higher success rates at subsequent attempts. It has never been investigated whether a planned investment procedure, with an intention that both the initial and staged completion PCI are of shorter duration, could improve safety and efficacy. The investigators hypothesize that A planned investment procedure in the treatment of CTOs will be associated with improved patient safety A planned investment procedure will be associated with improved cumulative procedure success rates A planned two stage procedure will be associated with improved patient experience
Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive...
Coronary Microvascular DysfunctionMicrovascular Angina5 moreEXAMINE-CAD-DZHK22 is a prospective, randomized, double-blind, placebo-controlled, crossover trial investigating the efficacy of beta blocker (bisoprolol) and calcium channel blocker (diltiazem) therapy in symptomatic patients with non-obstructed coronary arteries according to coronary physiological testing results.