Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep...
Obstructive Sleep ApneaThe purpose of this study is to evaluate the benefits and risks of hypoglossal nerve stimulation with the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System as a potential therapeutic option for individuals with moderate to severe Obstructive Sleep Apnea (OSA) that have failed or do not tolerate positive airway pressure (PAP) therapy.
Nasal Expiratory Resistance in Patients With Sleep Apnea and Expiratory Flow Limitation
Obstructive Sleep ApneaObstructive sleep apnea (OSA) is inherently site-specific. In a physiological controlled intervention study, the investigators seek to determine whether applying expiratory resistance can acutely improve ventilation and sleep in patients with expiratory flow limitation (EFL).
Treatment of Central Sleep Apnoea in Patients With Heart Failure With Nasal High Flow Therapy (nHFT)...
Central Sleep ApneaCheyne-Stokes RespirationTo investigate whether nHFT is an effective treatment for patients with Chronic Heart Failure (CHF) and central sleep apnea (CSA). This study is a prospective one armed uncontrolled intervention pilot study investigating 4 weeks of nHFT at home in 10 patients with CHF and CSA.
CALLSAS Study: Effect of Continuous Positive Airway Pressure Treatment for Obstructive Apnea on...
Sleep ApneaObstructiveContinuous positive airway pressure (CPAP) treatment improves sleepiness, depression and social activities in patients with obstructive sleep apnea (OSA). This evolution can be captured from changes in phone usage habits coupled with a mobile-based services. The aim of this study is to assess the impact of CPAP treatment on phone usage habits in OSA patients.
Cycloserine in the Treatment of Sleep Apnea
Sleep Apnea SyndromesThis study is being conducted to determine whether cycloserine is effective for the treatment of sleep apnea. Cycloserine is an antibiotic that has been extensively used in the treatment tuberculosis. However, more recently it was shown to enhance memory responses. Cycloserine may enhance the response of respiratory muscles to apnea and potentially reduce the severity of sleep disordered breathing.
Systemic Inflammation and Obstructive Sleep Apnea Syndrome: Effect of Atorvastatin
Obstructive Sleep Apnea SyndromeThe aim of this clinical trial is to evaluate the effect of Atorvastatin on the endothelial function improvement during the obstructive sleep apnea syndrome (OSAS) after 3 months of treatment, by a double-blind, randomized, placebo-controlled, multi-center study. An interim analysis will be performed when 25 patients per group will be included.
Effect of Fenofibrate on Sleep Apnea Syndrome
DyslipidemiaSleep Apnea Syndrome2 moreObjectives: to investigate for the potential effect of fenofibrate on symptoms and biological changes associated with sleep apnea syndrome.
Sleep Apnea and Fetal Growth Restriction
Obstructive Sleep ApneaFetal Growth Restriction1 moreThis study aims to evaluate the association between obstructive sleep apnea (OSA) and fetal growth restriction (FGR) and to assess the role of auto-titrated positive airway pressure (aPAP) as antenatal therapy in these patients. Pregnant patients with diagnosed FGR will be screened for OSA first by screening questionnaire and then by home sleep monitor. Of those patients diagnosed with OSA, half will be assigned to use aPAP each night when sleeping and half will not (standard care).
Hill-Rom WAVE for Positional Obstructive Sleep Apnea at Home
Sleep ApneaObstructiveDetermine the effects of a mattress support (Wave 4.3) that promotes the avoidance of supine airway position at home on the apnea-hypopnea index (AHI) in patients with positional obstructive sleep apnea (OSA). Determine the effects of Wave 4.3 on subjective measures of sleepiness and daytime function in patients with positional OSA. Determine the effects of Wave 4.3 on subjective measures of sleep quality in patients with positional OSA.
The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients...
Heart FailureCentral Sleep ApneaThe purpose of this trial is to evaluate the long-term effects of Nocturnal Oxygen Therapy (NOXT) on the mortality and morbidity of patients with stable heart failure and a reduced ejection fraction (HFrEF), already receiving optimal guideline-directed medical therapy (GDMT), who have central sleep apnea (CSA).