Coronary Artery Disease (CAD) in Postmenopausal Women
Postmenopausal WomenStable Angina PectorisAim of this study is the determination of a valid procedure for ischemia diagnositc in postmenopausal women.
Scottish COmputed Tomography of the HEART Trial
Angina PectorisCoronary Heart DiseaseThe primary objective of the study is to see if coronary artery calcium score and computed tomography coronary angiogram alters the proportion of patients diagnosed with angina due to coronary heart disease.
Imaging and Biomarkers of Atherosclerosis in Patients With Stable or Unstable Coronary Artery Disease...
AtherosclerosisCoronary Artery Disease1 moreIn this study, multimodal imaging of atherosclerosis and dosage of new circulating biomarkers will be used to compare patients with stable or unstable coronary artery disease
Stress Echocardiography and Heart Computed Tomography (CT) Scan in Emergency Department Patients...
Chest PainAngina2 moreThe purpose of this study is to determine whether stress echocardiography or computed tomography (CT) of the heart is better at diagnosing emergency room chest pain patients to select appropriate candidates for hospitalization and further work-up.
Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS)
Coronary ArteriosclerosisCardiomyopathies3 moreMultidetector Computed Tomographic Coronary Angiography (MDCTCA) has been recently demonstrated to be accurate and may be used as a potential alternative to conventional invasive coronary angiography, which requires cardiac catheterization, for the diagnosis of coronary artery disease. The purpose of this study is to see if MDCTCA can identify significant coronary artery disease as good as or better than conventional coronary angiography (CICA). The study is designed to enroll 900 subjects and is being conducted in 6 hospitals in Ontario. Subjects scheduled for conventional cardiac catheterization and coronary angiography will receive an additional test using MDCTCA. The information gathered during the MDCTCA will be compared to the results of the scheduled conventional invasive coronary angiogram.
Optical Coherence Tomography (OCT) Evaluation of Re-endothelization: A Comparison of the Intrepide™...
Coronary Artery DiseaseAcute Coronary SyndromePatients presenting with ACS (Acute Coronary Syndrome) in the emergency department will be screened for clinical eligibility and asked to sign informed consent to the study. A total of 40 patients will be randomized. 20 of them will receive a Trapidil eluting stent (Intrepide™ stent), 20 will receive a Paclitaxel eluting stent (Taxus™ stent). After 90 days the patients who were treated with the INTREPIDE stent in the first lesion will be treated with the Taxus stent in the second lesion. After 90 days the patients who were treated with the Taxus stent in the first lesion will be treated with the INTREPIDE stent in the second lesion. Coronary angiography will be performed through the femoral (groin) or radial (wrist) artery with the use of standard techniques. The doctor will determine if the patient is qualified for enrolment at the end of the diagnostic coronary angiogram
Prompt Human Coronary Collateral Vasomotor Function Induced by Dynamic Physical Exercise
Coronary Artery DiseaseThe purpose of this study in humans with stable coronary artery disease (CAD) treatable by PCI (percutaneous coronary intervention) is to evaluate if dynamic physical exercise leads to an instantaneous improvement of coronary collateral function.
Stenting With or Without Coating Compared With Angioplasty in Non-benestent Disease
Coronary Artery DiseaseThe purpose of this study is to evaluate the clinical and angiographic outcome of implantation of stents eluting or not eluting Sirolimus in patients with complex coronary artery lesions suitable for percutaneous coronary intervention.
One-Dimensional Mathematical Model-Based Automated Assessment of Fractional Flow Reserve
Coronary Artery DiseaseThis study evaluates the diagnostic efficiency of an automated method of noninvasive assessment of the fractional reserve of coronary blood flow. Fractional flow reserve is estimated with a one-dimensional mathematical model constructed by means of an automated algorithm. Noninvasive method values are thereafter compared with invasive method values.
Robotic-Assisted Percutaneous Coronary Intervention
Coronary Artery DiseasePercutaneous coronary intervention is a safe procedure. However, its execution is manual, fully operator-dependent. The procedure is also associated with radiation exposure to patients and physicians. This study will evaluate the robotic assisted percutaneous coronary intervention as an alternative to manual operation.