Dalbavancin For The Treatment of Gram Positive Osteoarticular Infections
Bone InfectionOsteomyelitis3 moreBecause of its prolonged terminal half-life, dalbavancin is an extremely attractive option in treating Gram-positive infections caused by S. aureus including MRSA, and streptococcal species. Systemic bacterial infections due to Staphylococci such as osteomyelitis and septic arthritis, are conditions which require prolonged IV therapy, typically for at least 3-6 weeks, though sometimes more. Due to dalbavancin's prolonged terminal half-life, it may offer the opportunity to substantially reduce costs and morbidity in native joint and prosthetic joint infections with one infusion every fourteen days until completion of therapy.
Oral Sodium Fusidate (CEM-102) for the Treatment of Staphylococcal Bone or Joint Infections
Refractory Bone or Joint InfectionsTo evaluate the safety and effectiveness of oral sodium fusidate (CEM-102) as chronic antibiotic for the treatment of bone or joint infections.
Tedizolid Prolonged Treatment for Prosthetic Joint Infections
Prosthetic Joint InfectionPilot study the aim of which is to obtain reliable data on the tolerance, compliance and efficacy of Tedizolid used as prolonged (≥ 6 weeks) monotherapy or in combination therapy for the treatment of patients with orthopedic device infections due to Gram positive cocci.
Antibiogram and Biofilm Formation of Bacteria Causing Prosthetic Joint Infections Isolated From...
Prosthetic Joint InfectionSetting of antibiogram in orthopedic department Evaluate the production of biofilm in bacteria isolated from specimens phenotypically and genotypically.
Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections...
Prosthetic Joint InfectionThe objectiveof this of a prospective, multicentre study is to evaluate the performance of shotgun metagenomics in the diagnosis of chronic Prosthetic joint infection (PJI) in comparison with the adapted MSIS diagnostic score.. The main questions it aims to answer are: To evaluate the performance of shotgun metagenomics in the diagnosis of chronic PJI in comparison with culture. To describe the epidemiology of bacterial species responsible for chronic PJI in Western France and their potential resistance to antibiotics. Analyzing the diagnostic performance of shotgun culture and metagenomics as a function of potentially administered antibiotic treatments A total of 143 patients sampled will be included. Six intraoperative samples will be taken for each patient, as part of routine care. In addition to the standard preoperative check-up, an extra volume of blood will be taken for CRP measurement at inclusion.
Ankle Joint Replacement Outcomes Study
OsteoarthritisRheumatoid Arthritis3 moreThis post market outcome study will look at the therapeutic results of the Salto Talaris Anatomic ankle prosthesis. The study population will consist of patients who will undergo an ankle arthroplasty procedure with a Salto Talaris ankle implant. An analysis will be conducted of the results, complications and revisions of this prosthesis based on the etiology for which the ankle arthroplasty was performed.
Two Versus Four Weeks of Antibiotic Treatment in Native Joint Arthritis
ArthritisSepticThe optimal duration of systemic antibiotic administration for native joint septic arthritis is unknown. The investigators perform a randomized study allowing up to 3 surgical lavages and allocating patients into a two-week's and a four week's randomization arm
Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis
Septic ArthritisInflammatory Arthritis1 moreThe purpose is to found new biomarker that differentiate septic arthritis and Juvenile Idiopathic Arthritis in children. Synovial liquid and blood samples with proteomic, MiRNA searching, multiplex cytokine analysis and cellular phenotyping, will be analysed. The results for each data will be compared in function of the disease to search discriminant markers. On behalf with this result specific pathways could be identified .
Oral Versus Intravenous Antibiotics for Bone and Joint Infections (OVIVA B&J)
Bone InfectionJoint InfectionThe study will compare the outcomes of treating bone and joint infections with 6 weeks of intravenous antibiotics with 6 weeks of oral antibiotic treatment. The trial is of antibiotic "strategy" rather than of individual antibiotics. The study will be open label, but the primary outcome will be proven failure of infection treatment, determined by pre-established objective criteria for treatment failure. The null hypothesis tested is that there will be no difference in treatment failure rates.
Bacteriophage Therapy in Patients With Prosthetic Joint Infections
Prosthetic Joint InfectionThis is a study designed to evaluate bacteriophage therapy in patients with chronic prosthetic joint infections.