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Active clinical trials for "Atherosclerosis"

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The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases

AtherosclerosisContrast Induced Nephropathy1 more

The purpose of this research is to determine the relationship between novel blood tests for heart function (including hormones and heart enzymes measured in the blood), and assess for kidney damage before and after angiography (cardiac catheterization). We hypothesize that these novel tests will enable us to predict possible complications of catheterization immediately after the procedure.

Completed4 enrollment criteria

Whole-Body MRA at 3T - A Comparison Between Two Different Scan Protocols

AtherosclerosisIntermittent Claudication

To compare to different approaches in whole-body magnetic resonance angiography of patients suffering peripheral arterial disease. Our hypothesis is that use of a new protocol improves the diagnostic quality of the WB-MRA procedure.

Completed8 enrollment criteria

Carotid Atherosclerotic Plaque Study

Atherosclerosis

First, to establish a comparison of the pathophysiology of carotid atherosclerosis and the genetic and environmental variables that cause those plaques to become symptomatic. Second, to differentiate between vulnerable plaque and other types of plaque using ultrasound elastography, MRI data, trans-cranial doppler along with RF (radio frequency) analysis of back-scattered ultrasonic echoes.

Completed2 enrollment criteria

Diabetes Genome Project: A Prospective Registry to Identify Genetic Variation Among Diabetic Patients...

Diabetes MellitusInsulin Resistance1 more

Previous scientific research has found multiple genes that affect the risk for developing heart disease or complications during the treatment of heart disease. Less is currently known about how patients with heart disease may differ on the basis of other ailments they may have and how these other ailments may affect their treatment and prognosis. For this reason, researchers at the Mid America Heart Institute are conducting this research to find out how genes affect heart disease and recovery following angioplasty. The study will include patients with diabetes in order to determine if their genes are different from patients without diabetes. A total of 1,607 patients were enrolled. There were 2 groups of patients selected for this study. The first group of patients included into the study will be those that are scheduled to have a diagnostic angiogram only. The second group of patients were those that had along with the angiogram a percutaneous transluminal coronary angioplasty, PTCA and or the use of a device called a coronary "stent", designed to help prop open the artery and to help avoid collapse. Samples for both groups will be stored for 30 years. After this time, all samples will be destroyed. Ultimately, we are hopeful that we will identify genes that will identify groups of patients at risk for heart disease.

Completed4 enrollment criteria

Epidemiology of Vascular Inflammation & Atherosclerosis

AtherosclerosisCardiovascular Diseases5 more

To investigate the relationship of vascular cell phenotypes to atherosclerosis.

Completed1 enrollment criteria

Genetic and Environmental Determinants of Triglycerides (GOLDN)

AtherosclerosisCardiovascular Diseases1 more

To characterize the genetic basis of the variable response of triglycerides to two environmental contexts, one that raises triglycerides (dietary fat), and one that lowers triglycerides (fenofibrate treatment.)

Completed14 enrollment criteria

Comparison of Coronary CT Angiography to Invasive Coronary Angiography

AtherosclerosisCoronary

The purpose of the trial is to investigate the accuracy of coronary CT compared to the conventional "gold standard" cardiac catheterization.

Unknown status10 enrollment criteria

Dietary Antioxidants and Atherosclerosis

AtherosclerosisCardiovascular Diseases2 more

To examine the role of dietary antioxidants in the etiology of atherosclerosis in both sexes and in whites and Blacks.

Completed1 enrollment criteria

Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors...

Carotid AtherosclerosisMyocardial Infarction

Iron has been proposed to contribute to atherogenesis in humans by facilitating the oxidation of lipoproteins. This observational study will evaluate the association between frequency of blood donation - expected to be associated with relatively reduced body iron stores in frequent donors - and carotid atherosclerosis. The primary outcome variable will be whether the presence and extent of asymptomatic carotid atherosclerosis as measured by ultrasound is greater in infrequent (less than or equal to 1 donations/year greater than or equal to 5 years) vs. frequent (greater than or equal to 4 donations/year greater than or equal to 5 years) blood donors. Body iron stores, lipid and hemostatic parameters, nitric oxide formation, inflammatory parameters, and markers of vascular oxidative stress will be analyzed as secondary outcome measures. Laboratory analysis and ultrasound testing will be performed blinded to the patient's phlebotomy and iron status. Sixty frequent (n=40 males greater than 40 y/o, n=20 females greater than 50 y/o) and 60 infrequent (n=40 males greater than 40 y/o, n=20 females greater than 50 y/o) blood donors will be recruited for this study from the Department of Transfusion Medicine, W. G. Magnuson Clinical Center. All donors will be assessed for study eligibility and cardiovascular risks during the screening visit. The presence of atherosclerotic lesions by carotid ultrasound and secondary outcome parameters will be assessed during a second visit.

Completed8 enrollment criteria

Cardiac MR of Subclinical CVD: Impact of Age

AtherosclerosisHeart Diseases3 more

To use magnetic resonance imaging to identify subclinical atherosclerosis and left ventricular hypertrophy in the Framingham Heart Study cohort.

Completed1 enrollment criteria
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