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Active clinical trials for "Bacterial Infections"

Results 481-490 of 589

Study of Adverse Effects Occuring in Patients Receiving an Antibiotic Treatment With Temocillin...

Bacterial Infection With One or More Extended Spectrum Betalactamases Remaining Susceptible to Temocillin

The Temocillin prescription frequency may be increased in order to reduce the use of carbapenems to reduce the progressive increase in carbapenem resistance observed in recent years. The investigators wish to study the responsibility of Temocillin in the occurrence of adverse effects in patients in the hospital of Amiens receiving a treatment containing this molecule.

Completed6 enrollment criteria

Wound Infection Detection Evaluation, WIDE

Wound Infection BacterialUlcer Foot2 more

Chronic wounds, such as diabetic foot ulcers, place a huge burden on healthcare systems and can lead to complications with high morbidity, particularly if the wound if infected. In parallel, there is pressure to reduce the use of antibiotics in order to minimise the risk of antimicrobial resistance. The Glycologic wound detection kit (GLYWD) is a point-of-care test, designed to provide guidance to clinical staff as to whether a chronic wound is infected or not. In this prospective cohort study the premise of this mode-of-action is evaluated. GLYWD will be applied in conjunction with clinical opinion and microbiological testing to determine if there is concordance between the different diagnostic approaches, and if applicable how they may differ in certain patients' wounds.

Completed15 enrollment criteria

Bleeding Ulcer and Erosions Study "BLUE Study"

Bacterial Infection Due to Helicobacter Pylori (H. Pylori)Peptic Ulcer1 more

A prospective study of bleeding peptic ulcers and/or erosions in the upper gastrointestinal tract - risk-medication, presence of Helicobacter pylori, treatment and outcome.

Completed7 enrollment criteria

Host RNA Profiles to Detect Infections in Young Infants

Bacterial InfectionsUrinary Tract Infections8 more

This study seeks to identify and test host RNA expression profiles as markers for infections in young infants. Preliminary studies have shown high sensitivity and specificity for the discrimination of bacterial from non-bacterial infections in children, but the method has only been investigated in a limited number of young infants. The study aims to include 65 young infants with serious bacterial infections. The samples will be analysed by RNA sequencing. New diagnostic tools may help reduce unnecessary antibiotic treatment, antibiotic resistance, side-effects, hospitalisation and invasive procedures.

Completed9 enrollment criteria

A Rapid Test for Acute Respiratory Illness

Respiratory Tract Infection AcuteTranscriptome2 more

The primary purpose of this study is to support the development of a host response test for acute respiratory illness to identify bacterial, viral or NB/NV etiologies as compared to a clinical adjudication reference standard. Secondary objectives include: Evaluate the effect of age on the performance of the HR-ARI test Evaluate the effect of race/ethnicity on the performance of the HR-ARI test Evaluate the effect of geography on the performance of the HR-ARI test

Completed8 enrollment criteria

Analysis of Immune Response In Bacterial Infection of Obese Subject

Obesity

Improve knowledge of the immune response to sepsis in obese patients. Define immunological and genetic prognostic factors of severe infections which can motivate a change in the therapeutic attitude

Completed22 enrollment criteria

Increase in Procalcitonin Kinetics May be a Good Indicator of Starting Empirical Antibiotic Treatment...

Bacterial Infection

The value of procalcitonin change from the day before to the day when infection was suspected in predicting bacterial infection in intensive care patients.

Completed11 enrollment criteria

Infant Antibiotic Resistance and Implications for Therapeutic Decision-making

Bacterial Infections and Mycoses

Escalating resistance to antibiotics among disease-causing community bacteria increasingly threatens our ability to treat patients' infections. At the level of the physician-patient encounter, incentives at the patient level often take priority to society; this is often the case with antibiotic prescribing. Each patient level antibiotic treatment decision is based on how we value potential outcomes, including short-term benefits and risks and longer-term risks, including those related to future bacterial resistance to antibiotics. Unfortunately, antibiotics are often prescribed for illnesses unlikely to have a bacterial etiology; even a very small likelihood of benefit seems to outweigh an increased risk of future antibiotic resistance. While short-term effects of antibiotics on colonization with resistant bacteria have been demonstrated, the overall implications of each treatment for future individual, family and societal-level resistance remain difficult to quantify, and are often steeply discounted or ignored during decision-making. Knowledge regarding the longer-term effects of personal and household antibiotic use could better quantify these future resistance-related risks, and help guide antibiotic decision-making for physicians and patients. Infants are born with sterile nasopharyngeal and gastrointestinal tracts and yet, during the 1st year of life, become important reservoirs of resistant organisms; this creates an opportunity to study colonization and resistance starting from a microbiological tabula rasa. In this proposal, we will use an observational cohort to following newborns' antibiotic exposure and longitudinal colonization with specific bacterial pathogens and related antibiotic resistance in the 1st year of life. Our hypothesis is that during the 1st year of life, infants with personal and household antibiotic exposure will have greater colonization with resistan organisms than infants without antibiotic exposure. This project will help us understand the development of bacteria that are resistant to antibiotics within the community, and help to inform judicious decision-making regarding antibiotic prescribing.

Completed6 enrollment criteria

Meropenem Plasma Concentration Measurements at the Pediatric Medical Ward, Oslo University Hospital,...

Bacterial Infection

The object of the study is to investigate whether all included patients receive treatment that is effective against all bacteria that are defined as sensitive to meropenem with the current treatment regimen. Will the investigators findings motivate routine monitoring of plasma concentrations in children receiving meropenem? Up to 50 patients will be included in the study, and all participants are children.

Completed2 enrollment criteria

ALTARGO(Retapamulin) PMS(Post-marketing Surveillance)

Skin InfectionsBacterial

This is an open label, multi-centre, non-interventional post-marketing surveillance.

Completed7 enrollment criteria
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