![National Cancer Institute (NCI)](https://trials-media.s3.amazonaws.com/orgs/national-cancer-institute-nci.jpeg)
Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer
Recurrent Bladder CarcinomaStage I Bladder Cancer AJCC v6 and v72 moreStudying samples of blood, urine, and tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer. It may also help doctors learn how genistein or placebo works in patients with bladder cancer. This randomized phase II trial is studying genistein or placebo to compare how they work in patients who are undergoing surgery for bladder cancer.
![University of Michigan Rogel Cancer Center](https://trials-media.s3.amazonaws.com/orgs/university-of-michigan-rogel-cancer-center.jpeg)
Paclitaxel, Carboplatin and Gemcitabine in the Treatment of Patients With Advanced Transitional...
Bladder CancerThis trial will evaluate the efficacy and safety of combination chemotherapy (paclitaxel, carboplatin, and gemcitabine) prior to surgery in the treatment of patients with locally advanced transitional cell cancer of the bladder.
![SWOG Cancer Research Network](https://trials-media.s3.amazonaws.com/orgs/swog-cancer-research-network.jpeg)
S0353, Gemcitabine in Treating Patients With Recurrent Bladder Cancer That Has Not Responded to...
Bladder CancerRATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving gemcitabine directly into the bladder may kill more tumor cells. PURPOSE: This phase II trial is studying how well gemcitabine works in treating patients with recurrent bladder cancer that has progressed despite previous Bacillus Calmette-Guerin (BCG).
![Radiation Therapy Oncology Group](https://trials-media.s3.amazonaws.com/orgs/radiation-therapy-oncology-group.jpeg)
Combination Chemotherapy and Radiation Therapy With/Without Surgery In Patients With Stage II/III...
Bladder CancerRATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy (RT) uses high-energy x-rays to damage tumor cells. It is not yet known which regimen of combination chemotherapy plus radiation therapy with or without surgery is more effective in treating bladder cancer. PURPOSE: Randomized phase II trial to study the effectiveness of two combination chemotherapy regimens and radiation therapy with or without radical cystectomy in treating patients who have stage II or stage III bladder cancer.
![University Health Network, Toronto](https://trials-media.s3.amazonaws.com/orgs/university-health-network-toronto.jpeg)
Tipifarnib in Treating Patients With Recurrent Bladder Cancer
Bladder CancerRATIONALE: Tipifarnib may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth. PURPOSE: Phase II trial to study the effectiveness of tipifarnib in treating patients who have recurrent bladder cancer.
![Cancer Research UK](https://trials-media.s3.amazonaws.com/orgs/cancer-research-uk.jpeg)
Suramin in Treating Patients With Recurrent Bladder Cancer
Bladder CancerRATIONALE: Suramin may stop the growth of bladder cancer by stopping blood flow to the tumor. PURPOSE: Phase I trial to study the effectiveness of suramin in treating patients who have recurrent bladder cancer.
![National Cancer Institute (NCI)](https://trials-media.s3.amazonaws.com/orgs/national-cancer-institute-nci.jpeg)
LMB-9 Immunotoxin in Treating Patients With Advanced Solid Tumors
Bladder CancerBreast Cancer5 moreRATIONALE: The LMB-9 immunotoxin may be able to locate tumor cells and kill them without harming normal cells. This may be an effective treatment for advanced solid tumors. PURPOSE: Phase I trial to study the effectiveness of LMB-9 immunotoxin in treating patients who have advanced solid tumors that have not responded to standard therapy.
![University of Chicago](https://trials-media.s3.amazonaws.com/orgs/university-of-chicago.jpeg)
Vinorelbine and Paclitaxel Plus Radiation Therapy in Treating Patients With Advanced Cancer Arising...
Bladder CancerCervical Cancer2 moreRATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy with may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of chemotherapy with vinorelbine and paclitaxel plus radiation therapy in treating patients with advanced cancer arising in the pelvis.
![Eastern Cooperative Oncology Group](https://trials-media.s3.amazonaws.com/orgs/eastern-cooperative-oncology-group.jpeg)
Chemotherapy in Treating Patients With Early-Stage Bladder Cancer
Bladder CancerRATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of chemotherapy in treating patients with early-stage bladder cancer that has not responded to BCG therapy.
![BeiGene](https://trials-media.s3.amazonaws.com/orgs/beigene.jpeg)
Study of Tislelizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer...
Locally Advanced or Metastatic Urothelial Bladder CancerThis was a single-arm, multicenter, Phase 2 study to evaluate the efficacy and safety of the anti- programmed cell death-1(PD-1) monoclonal antibody BGB-A317 in participants with PD-L1+, locally advanced or metastatic Urothelial Bladder Cancer (UBC) who have progressed during or following a platinum-containing regimen