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Active clinical trials for "Brugada Syndrome"

Results 1-10 of 43

Brugada Syndrome Substrate Characterization and Ablation

Brugada Syndrome

Independent, single center, prospective study, to evaluate the efficacy, in consecutive BrS patients undergoing catheter ablation, at medium-long term follow-up after epicardial substrate homogenization. The target area is defined collecting signals using high density and high resolution mapping with equi-spaced electrode array. The ablation of abnormal fragmented prolonged low-frequency ventricular electrograms is performed by contact force catheter.

Recruiting10 enrollment criteria

Invasive and Clinical Features in Patients With Brugada Syndrome Undergoing Catheter Ablation

Brugada Syndrome

This clinical trial aims to learn about the electrophysiological and clinical effects of radiofrequency catheter ablation in patients with Brugada syndrome. The main questions it seeks to answer are: What are the immediate effects of catheter radiofrequency ablation in cardiac electrophysiology? What is the relation between invasive and clinical features in patients with Brugada syndrome undergoing ablation? Researchers will compare ablation and control groups to see if there is a difference in clinical and invasive markers of the disease in one year of follow-up.

Recruiting8 enrollment criteria

Epicardial Ablation in Brugada Syndrome. An Extension Study of 500 BrS.Patients

ECG Brugada Pattern

This study represents an extension of a previous study (NCT02641431) on the acute and long-term benefit of epicardial ablation on elimination of both BrS-ECG pattern and VT/VF inducibility in 500 consecutive BrS patients.

Recruiting2 enrollment criteria

Ablation in Brugada Syndrome for the Prevention of VF

Brugada Syndrome

This trial aims to develop evidence based curative treatment with optimal net benefit for patients with Brugada syndrome.

Recruiting10 enrollment criteria

Epicardial Ablation in Brugada Syndrome to Prevent Sudden Death

Ventricular Arrhythmias and Cardiac Arrest

A total of 150 patients will be randomized to perform catheter ablation or not in a 2:1 fashion in selected patients with Brugada-related symptoms (Ablation+ICD arm 105 patients vs ICD only 45 patients).

Recruiting11 enrollment criteria

Worm Study: Modifier Genes in Sudden Cardiac Death

Brugada SyndromeLong QT Syndrome 3

Quest for modifier genes associated with ventricular arrhythmias in presence of a cardiac sodium channel gene (SCN5A-delPhe1617) mutation.

Recruiting14 enrollment criteria

Clinical Cohort Study - TRUST

ArrhythmiasCardiac11 more

The "Long-term Outcome and Predictors for Recurrence after Medical and Interventional Treatment of Arrhythmias at the University Heart Center Hamburg" (TRUST) study is an investor-initiated, single-center, prospective clinical cohort study including patients treated with cardiac arrhythmias or at high risk for cardiac arrhythmias. The design enables prospective, low-threshold, near complete inclusion of patients with arrhythmias treated at the UHZ. Collection of routine follow-up data, detailed procedural information and systematic biobanking will enable precise and robust phenotyping.

Recruiting6 enrollment criteria

Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations

Long QT SyndromeBrugada Syndrome5 more

The QUALIMYORYTHM trial is a multicentre controlled study, aiming to assess health-related quality of life (HRQoL) of 107 children aged 6 to 18 years old with inherited cardiac arrhythmia (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, or arrhythmogenic right ventricular dysplasia), or inherited cardiomyopathies (hypertrophic, dilated, or restrictive cardiomyopathy), and to compare the results to those of 107 age and gender-matched healthy subjects. The secondary objective is to assess, in this population, the HRQoL according to disease characteristics, level of physical activity, exercise capacity, and socio-demographic data. Participants will wear a fitness tracker for 2 weeks.

Recruiting7 enrollment criteria

Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in...

Long QT SyndromeBrugada Syndrome3 more

In patients expressing the SCN5A-E1784K mutation (Glu1784Lys), cardiovascular risk is difficult to define as the stratification of these patients is challenging. From our experience, major cardiovascular events (MCE) tend to occur more frequently in patients expressing overlap syndrome phenotype (Brugada syndrome and Long QT syndrome type 3)than in patients expressing a single phenotype (whether Brugada syndrome or Long QT syndrome type 3). This trials is led on the impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A ( RISKOVER )

Recruiting2 enrollment criteria

Sudden Unexplained Death in Childhood (SUDC) Registry

Sudden Unexplained Death SyndromeSudden Unexplained Death in Childhood

The purpose is to increase the understanding of the characteristics, circumstances, medical histories and pathologies of children from ages 11 months through 18 years who have died suddenly and unexpectedly, and in some instances, without explanation. The SUDC Registry and Research Collaborative will analyze cases of sudden unexpected deaths in these children to understand risk factors and causes, and develop preventative measures.

Recruiting14 enrollment criteria
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