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Active clinical trials for "Marijuana Abuse"

Results 421-430 of 435

Cannabis Use and Epigenetic Alterations in Human Male Sperm Cells

Cannabis Use

This is a follow-up project to a proof-of-concept study to determine if Cannabis use in male humans is associated with changes in deoxyribonucleic acid (DNA) methylation profile of sperm. This proposal will examine the epigenome of sperm from men actively using Cannabis before and after a period of Cannabis abstinence. The results will be compared to control non-users.

Completed24 enrollment criteria

Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms

Cannabis AbuseCannabis Dependence

Background: - Marijuana is the most widely used illicit drug in the world, yet relatively little is known about users who try to quit without formal treatment ( spontaneous quitting). Studies have suggested that there are some common strategies that many individuals use in spontaneous quitting, such as changing one s lifestyle or identity, reminding oneself of negative consequences, support from family and friends, and religion. However, more research is needed to determine potential treatment strategies for marijuana use. Objectives: To identify strategies used to help with marijuana quitting among non-treatment seeking adult marijuana users. To identify withdrawal symptoms experienced during marijuana quitting and their relationship to the quitting strategies used and the outcome of the quit attempt. To evaluate whether subgroups of marijuana users differ in their experience of marijuana quitting. Eligibility: - Individuals at least 18 years of age who have made at least one attempt to quit marijuana use. Design: The study will consist of one visit of approximately 1 to 2 hours. Participants will fill out three questionnaires. The questionnaires have different types of questions, and will ask about background and lifestyle, marijuana use and craving patterns and behaviors, and difficulties in previous attempts to quit using marijuana.

Completed4 enrollment criteria

Emotional Brain Processes in Recreational Cannabis Users

Recreational Cannabis Use

This fMRI study investigates neural correlates of emotion regulation, emotion processing and craving in recreational cannabis users.

Completed4 enrollment criteria

A Comparison of Post-Operative Analgesia Requirements In Recreational Cannabis Users Versus Cannabis...

Cannabis UseOpioid Consumption

Cannabis is a drug that is widely used for recreational purpose. In most patients undergoing surgery, opioids are the most widely used mode of pain relief, during and following surgery. Anecdotally it has been observed that cannabis users required unexpectedly high doses of opioids. The purpose of this study is to compare opioid requirements between cannabis users and non- users after the surgery. Currently, post-operative opioid doses are determined based on various patient factors such as pre-operative opioid use, patient weight, age and sensitivity to opioids during surgery. Patients' requirements may be underestimated and opioid regimens need to be escalated in the first 24 hours in order to alleviate uncontrolled pain in cannabis users. Better understanding of the impacts of cannabis use on post-operative opioid requirements would help the Acute Pain Service optimize post-operative pain management for patients who use cannabis pre-operatively.

Completed4 enrollment criteria

Effects of Marijuana Used on Lung Function in Persons With Chronic Obstructive Pulmonary Disease...

Chronic Obstructive Pulmonary Disease

The main hypothesis is that persons that smoke or smoked tobacco and marihuana have worsen lung function as compared with persons that only smoke or smoked tobacco.

Completed4 enrollment criteria

Attempts to Stop/Reduce Marijuana Among Dependent Users

Marijuana AbuseMarijuana Dependence

The purpose of the study is to determine why and how marijuana users stop or reduce their marijuana use.

Completed2 enrollment criteria

Colorado Marijuana Users Health Cohort

COPDInsomnia1 more

In Colorado, marijuana is currently used for both recreational and medicinal purposes.To learn more about the positive and negative long term medical effects of marijuana use. Information obtained during this study may identify new markers that influence the development of lung diseases such as COPD. The Investigators are also interested in learning more about the effects of marijuana use for insomnia and how it may or may not affect sleep.

Unknown status17 enrollment criteria

Cannabinoides Concentrations and Hyperemesis Syndrom Occurrence in Regular Cannabis Consumer (CANEMESE)...

Chronic Consumption of Cannabis

The Cannabinoide Hyperemesis Syndrom (CHS) is defined as a recurrent syndrome of intractable vomiting that occurs in chronic cannabis consumers. The diagnosis is linked to clinical criteria only. The physiopathology of CHS is unknown and we observe an increase of cases with this syndrom since 2016 (Schreck et al., 2018). The aim of this study is to investigate the involvement of exogenous cannabinoids concentrations in chronic cannabis users in the occurrence of CHS.

Unknown status6 enrollment criteria

Evaluation of the Effect of tDCS on Cannabis Craving

Addiction to Cannabis

Cannabis is the most frequently consumed drug in France and its use continues to increase. Over the 18-64 age group as a whole, experimentation with cannabis at least once in a lifetime increased from 33% in 2010 to 42% in 2014, confirming the upward trend observed since the 1990. Cannabis, like all drugs, disrupts the reward circuit whose neurons originate in the ventral tegmental area and project into the mesolimbic and cortical structures. Acute cannabis use is thought to increase mesolimbic dopamine by affecting the Gabaergic or Glutamatergic system. Chronic cannabis use usurps the reward system and leads to changes in the mesolimbic circuit (nucleus accumbens, ventral tegmental area, amygdala, and prefrontal cortex), inducing increased craving, with persistent craving for the substance and vulnerability to relapse. Cognitively, addiction is associated with increased impulsivity, with a propensity to take risks leading to impaired decision-making. There is currently no validated drug treatment for cannabis addiction. Non-invasive brain stimulation could be an interesting therapeutic alternative.

Unknown status13 enrollment criteria

Effect of Cannabis and Cigarette Smoking on Oral Mucosa

Field Cancerization for Cannabis Smokers

The aim of this study is to detect P53 expression in clinically normal oral mucosa of cigarette smokers, simultaneous cigarette and cannabis smokers and non-smokers as a surrogate marker for field cancerization.

Unknown status5 enrollment criteria
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