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Active clinical trials for "Cardiomyopathies"

Results 611-620 of 1105

Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and...

Hypertrophic Cardiomyopathy

A Study on the Efficacy, Safety, and Tolerability of Perhexiline maleate in Subjects with Hypertrophic Cardiomyopathy and Moderate-To-Severe Heart Failure

Withdrawn39 enrollment criteria

Doxorubicin-associated Cardiac Remodeling Followed by CMR in Breast Cancer Patients

Breast Cancer FemaleDoxorubicin Induced Cardiomyopathy

Twenty-seven breast cancer women without heart failure, underwent CMR imaging (3T-Achieva, Philips) before and 3 times serially after 4-cycles of adjuvant DOX (60mg/m2). CMR assessed left ventricular (LV) ejection fraction (EF), T1 mapping pre and post gadolinium and late gadolinium enhancement imaging. Biomarkers were obtained before and 72 hours after each DOX-cycle.

Completed4 enrollment criteria

Assessment of Risk Factors for Appropriate ICD (Implantable Cardioverter-defibrillator) Intervention...

ICDCardiomyopathy Ischemic1 more

Design: PARCADIA is a prospective non-randomized non-interventional multi-center clinical investigation in Europe. Patients with depressed LV (left ventricular) function assessed on local standards, of ischemic origin and on chronic optimal medical therapy will be selected according to inclusion and exclusion criteria, implanted with an ICD after executing baseline investigations and prospectively followed up for minimal 24 months and until the termination of the clinical investigation. General objective: analysis of baseline risk factors to identify predictors for appropriate ICD intervention in patients with ischemic cardiomyopathy receiving an ICD for primary prevention (MADIT II population). Hypothesis: The primary alternative hypothesis states that the mean relative infarct transmurality (RIT) is different in patients with (RITshock or ATP (Anti Tachy Pacing)) and without (RITno shock or ATP )appropriate ICD intervention, i.e. shock or ATP. Null hypothesis (H0): RITshock or ATP = RITno shock or ATP Alternative hypothesis (Ha): RITshock or ATP ≠ RITno shock or ATP Sample size: 200 patients. Follow-up: Enrolment visit, pre implant screening, ICD implantation, pre-hospital discharge visit, and follow-up (FUP) visits at 2, 6, 12, 18, 24 months including home monitoring. Additional routine FUP every 6 months until study termination after last enrolled patient has completed 2 years FUP.

Completed12 enrollment criteria

Prevention Using Exercise Rehabilitation to Offset Cardiac Toxicities Induced Via Chemotherapy

Doxorubicin Induced CardiomyopathyBreast Cancer2 more

The purpose of this study is to identify patients at risk for future heart failure using novel markers of early cardiac damage and determine if exercise training can improve these emerging markers as well as overall fitness and quality of life.

Completed11 enrollment criteria

Effect of Aldosterone on Energy Starvation in Heart Failure

Heart FailureNonischemic Dilated Cardiomyopathy

We plan to study the concept of "energy starvation" in heart failure by evaluation of patients with nonischemic dilated cardiomyopathy (NIDCM) (heart failure with reduced heart pump function due to causes other than heart attack). We will use a combination of positron emission tomography and magnetic resonance imaging to study metabolism, anatomy, function, blood flow and efficiency, before and after 6 months' treatment with the drug spironolactone which blocks the deleterious effects of the hormone aldosterone on the myocardium (heart muscle).

Completed9 enrollment criteria

Study Tests Whether a Standardized LVR Performed With the Blue Egg Device Improves Cardiopulmonary...

Congestive Heart FailureIschemic Cardiomyopathy2 more

The purpose of the present prospective, randomized study is to investigate the clinical effectiveness of standardized left ventricular reconstruction surgery (LVR). In order to standardize the procedure, the operation will be performed with the Blue Egg, manufactured by BioVentrix, a subsidiary of CHF Technologies, Inc.

Withdrawn28 enrollment criteria

Neurohormonal Parameters in Hypertrophic Cardiomyopathies

1- Primary (Sarcomeric) Hypertrophic Cardiomyopathy2- Obstructive Hypertrophic Cardiomyopathy1 more

The primary purpose of this study is to demonstrate that changes in plasma levels of circulating neurohormones (mainly BNP and NT-proBNP), measured at rest and post-exercise correlate with exercise functional limitation (assessed by exercise peak VO2) and exercise ultrasonic parameters (as left ventricular filling, obstruction, and mitral regurgitation)

Completed17 enrollment criteria

Spironolactone Against Anthracycline-induced Cardiomyopathy

Anthracycline Induced Cardiotoxicity

This study sought to investigate the whether spironolactone protects the heart against anthracycline-induced cardiotoxicity.

Completed13 enrollment criteria

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEK162 in Noonan Syndrome Hypertrophic...

Cardiomegaly

The purpose of the study is to determine whether the ability of MEK162 to antagonize MEK activation in NS HCM patients, who usually have upstream mutations in the Ras-Raf-Mek-Erk pathway that lead to MEK activation, would be beneficial over a 6 month treatment period in hypertrophy regression.

Withdrawn10 enrollment criteria

Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

Heart FailureCardiomyopathy

The overall hypothesis of this application is that the improvement in LV ejection performance following treatment with betablockers is due, at least in part, to improvement in intrinsic myocardial contractility.

Completed18 enrollment criteria
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