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Active clinical trials for "Charcot-Marie-Tooth Disease"

Results 71-80 of 88

Disability Severity Scale (DSI) and Hereditary Motor and Sensory Neuropathy Overall Disability Scale...

Charcot Marie Tooth DiseaseInherited Peripheral Neuropathy

The purpose of this research study is to create and validate two patient reported outcome (PRO) questionnaires. PRO questionnaires ask questions that help to measure disability in patients with inherited neuropathies. These questionnaires ask questions about what participants think disability is for themselves or others with inherited neuropathies. These questionnaires are a useful tool when evaluating whether treatments are working in the day to day life of an individual, although there are currently no questionnaires available specifically for people who have Charcot Marie Tooth disease (CMT).

Completed9 enrollment criteria

Survey of Current Management of Orthopaedic Complications in CMT Patients

Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. Foot deformities are frequent complications in CMT patients and orthopaedic surgery is often required. As yet there are no systematic studies on the management of orthopaedic complications in CMT patients and the current approach varies between centres. This study is a survey with the aim of understanding the current surgical approach to orthopaedic complications in CMT. The target population includes orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in the Inherited Neuropathies Consortium (INC).

Completed4 enrollment criteria

Nerve Entrapment in Diabetic Patients

Carpal Tunnel SyndromeEntrapment Neuropathies2 more

The aim of this study is in a prospective, consecutive series of diabetic patients with carpal tunnel syndrome, who are then age and gender matched with non-diabetic patients having idiopathic carpal tunnel syndrome to compare the clinical results after carpal tunnel release.

Completed9 enrollment criteria

Follow up and Observation of Charcot Marie Tooth Disease in Families

Charcot-Marie-Tooth Disease

The study is aimed to test the hypothesis that there is anticipation in CMT

Completed1 enrollment criteria

Physical Activity in Persons With Charcot-Marie-Tooth: Developing a Measurement Instrument

Hereditary Motor and Sensory NeuropathyCharcot-Marie-Tooth1 more

The project will develop knowledge about physical activity in persons with Charcot-Marie-Tooth (CMT) in Norway. We plan to explore instruments to measure physical activity level for the target-group at the community level. We want to understand which type of activities, activity intensities and how persons with CMT perform habitual physical activity. Subsequently, a physical activity measurement instrument adapted to persons with CMT will be developed. This instrument can be used in a future intervention project to promote physical activity in this group.

Unknown status5 enrollment criteria

Abdominal Cutaneous Nerve Entrapment Syndrome

Abdominal PainAbdominal Cutaneous Nerve Entrapment Syndrome

Nerve entrapment as a cause of chronic abdominal pain is frequently overlooked. A series of nerves pass through the muscles of the abdomen before reaching the skin to carry sensations. They can get trapped within the muscles leading to severe pain resulting in a condition known as Abdominal Cutaneous Nerve Entrapment Syndrome (ACNES). ACNES affects between 10-30% of patients with chronic abdominal wall pain. A definitive diagnosis of ACNES is obtained by anaesthetising these nerves. Initial management includes education and avoidance of known triggers. It is common practice to inject steroid with local anaesthetic during the diagnostic injections itself to prolong pain relief. Like other nerve entrapment conditions, this is also refractory to medical treatment. Hence repeated injections and nerve entrapment release surgery are commonly carried out. In Aberdeen, a number of patients have been treated for this condition. A cohort of patients have benefitted with injection alone while recurrence has been noted in patients who have undergone surgery. This project aims to gain more understanding about the clinical course of patients with suspected ACNES by evaluation of the clinic progress.

Completed9 enrollment criteria

Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With...

Charcot-Marie-Tooth Type 1A Neuropathy

This exploratory cross-sectional study proposes, firstly, to objectify in a population of Charcot-Marie-Tooth disease type 1A (CMT 1A)if there is a correlation between the recording of electrical parameters and upper limb muscle strength of the thigh and in a second step, to seek a relationship between the measured parameters.

Completed11 enrollment criteria

An Analysis of the Symptomatic Domains Most Relevant to Charcot Marie Tooth Neuropathy (CMT) Patients...

Charcot Marie Tooth Disease (CMT)Hereditary Sensory and Motor Neuropathy7 more

The purpose of this study is to identify the issues that have greatest impact on QOL for patients with Charcot Marie Tooth (CMT) Disease. Patients who have -registered in the Inherited Neuropathies Consortium Contact Registry will be invited to participate.

Completed3 enrollment criteria

Nerve Morphology in Diabetic Patients

Peripheral NeuropathyCarpal Tunnel Syndrome2 more

The underlying basis of carpal tunnel syndrome and the basis of its increased incidence in diabetes are unknown. The aim of this study was to quantified pathology in an uncompressed nerve (posterior interosseous nerve in the forearm between diabetic and non-diabetic patients with CTS.

Completed10 enrollment criteria

Development and Validation of a Disability Severity Index for CMT

Charcot Marie Tooth Disease

It is necessary for outcome measures to accurately reflect the state of health of a person in order for clinical trials to show benefit. The most commonly used outcome measure for Charcot Marie Tooth Disease (CMT) is the CMT Neuropathy Score, which uses cutoffs of points designated as mild (0-10 points), moderate (11-20) or severe (21-36). These terms are arbitrary. This study is looking to base mild, moderate, and severe on what both people affected with CMT and those who provide for people with CMT consider appropriate.

Completed5 enrollment criteria
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