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Active clinical trials for "Cholangitis"

Results 91-100 of 254

Safety, Tolerability, and Efficacy of Cilofexor in Non-Cirrhotic Adults With Primary Sclerosing...

Primary Sclerosing Cholangitis

The primary objective of this study is to evaluate whether cilofexor reduces the risk of fibrosis progression among non-cirrhotic adults with primary sclerosing cholangitis (PSC).

Terminated21 enrollment criteria

Study to Evaluate the Safety, Tolerability, and Efficacy of Cilofexor in Adults With Primary Biliary...

Primary Biliary Cholangitis

The primary objective of this study is to evaluate the safety and tolerability of cilofexor in adults with primary biliary cholangitis (PBC).

Terminated20 enrollment criteria

A Research Study to Evaluate Safety and Efficacy of DUR-928 in Subjects With Primary Sclerosing...

Primary Sclerosing Cholangitis

This is a research trial testing DUR-928 (an experimental medication). The purpose of the trial is to assess whether treatment with DUR-928 has any effect on the treatment of Primary Sclerosing Cholangitis (PSC). This trial will also assess safety (side effects).

Terminated16 enrollment criteria

The INFECIR-2 Albumin Prevention Study

Advanced Chronic Liver DiseaseUrinary Infection3 more

The aim of this study is to evaluate whether albumin administration improves short-term survival in patients with advanced cirrhosis and bacterial infections other than Spontaneous Bacterial Peritonitis (SBP).

Terminated25 enrollment criteria

Study of Obeticholic Acid (OCA) Evaluating Pharmacokinetics and Safety in Participants With Primary...

Liver CirrhosisBiliary

This Phase 4, randomized, double-blind, placebo-controlled study will evaluate the pharmacokinetics (PK) and safety of OCA treatment in participants with PBC and moderate to severe hepatic impairment over a 48-week treatment period. Participants who have completed their 48-week double blind treatment period will continue double-blind treatment until all randomized participants have completed their 48-week treatment period and the database for that period is locked. An open-label extension study in which all participants receive OCA will be considered following review of blinded safety and PK data.

Terminated30 enrollment criteria

Safety, Tolerability, and Efficacy of Etrasimod (APD334) in Participants With Primary Biliary Cholangitis...

Primary Biliary Cholangitis

The purpose of this open-label, pilot, proof of concept study is to evaluate the safety, tolerability, and efficacy of oral etrasimod (APD334) in participants with primary biliary cholangitis (PBC).

Terminated16 enrollment criteria

Pilot Study of Fenofibrate for PSC

Primary Sclerosing Cholangitis

The purpose of this study is to determine whether fenofibrate is safe and effective in the treatment primary sclerosing cholangitis (PSC).

Terminated15 enrollment criteria

Study of E6011 in Japanese Subjects With Primary Biliary Cholangitis Inadequately Responding to...

Primary Biliary Cholangitis

This study is a placebo-controlled, randomized, double-blind, multicenter, parallel-group comparison study in primary biliary cholangitis participants inadequately responding to ursodeoxycholic acid.

Terminated34 enrollment criteria

Biliary Interventions in Critically Ill Patients With Secondary Sclerosing Cholangitis (BISCIT)...

Secondary Sclerosing Cholangitis

This is a randomized, open-label, controlled, parallel group, multicenter clinical trial. Patients with confirmed secondary sclerosing cholangitis (SSC-CIP) will be randomized either in the intervention group undergoing scheduled invasive evaluation of the biliary tract or in the control group treated with non-interventional standard of care to demonstrate that programmed endoscopic therapy compared to a conservative strategy reduces the occurrence of treatment failures.

Terminated20 enrollment criteria

Value of MRCP+ And Liver Multiscan in the Management of Dominant Strictures in Primary Sclerosing...

PSCMRI

Primary sclerosing cholangitis (PSC) is a chronic progressive biliary disease. Due to the heterogeneous disease course and the relatively low clinical event rate of 5% per year it is difficult to predict prognosis of individual patients. Novel imaging techniques called MRCP+ and Liver Multiscan (LMS) hold the prospect of adequate depicting and quantifying lesions of the biliary tree as well as capturing functional derailment. However, these features must be tested first. The purpose of this study is to assess the (i) ability of MRCP+ to detect change in biliary volume, (ii) reproducibility of MRCP+ and LMS, and (iii) correlation of MRCP+ with ERC findings as gold standard.

Not yet recruiting6 enrollment criteria
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