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Active clinical trials for "Cartilage Diseases"

Results 1-10 of 68

NOVOCART 3D Treatment Following Microfracture Failure

Articular Cartilage Defect

This study is prospective single arm extension study of protocol AAG-G-H-1220. It is open only to participants of AAG-G-H-1220 randomized to the Microfracture treatment group.

Recruiting7 enrollment criteria

All Autologous Cartilage Regeneration in the Treatment of the Knee Cartilage Defects

Cartilage DamageCartilage Disease

The cartilage articular defects of the knee are extremely disabling lesions and represent one of the predisposition causes to the development of articular arthrosis. When clinical symptoms are present, exist the indication to treat the patient surgically, to this end, several surgical techniques could be performed, as the microfractures, osteochondral transplantation (OCT) or chondrocytes autologous transplantation (ACT). The aim of this pilot study is to evaluate the clinical performance of a modified version of the ACT technique, the All Autologous Cartilage Repair technique (AACR). A one-step technique in which the healthy cartilage harvested is fragmented directly in situ and then mixed with the autologous platelet concentrate and directly injected in the cartilage defect.. This lead to a less invasive surgery and cost-effective procedure. The performance will be evaluated through the evaluation of clinical results and complications after surgery other than the evaluation of the quality of the cartilage tissue repaired.

Recruiting16 enrollment criteria

Phase 2 Clinical Trial of CartiLife® in the United States

Articular Cartilage DefectArticular Cartilage Degeneration

To evaluate the safety and efficacy of implanting pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject with articular cartilage defects of the knee as a result of trauma or degeneration.

Recruiting38 enrollment criteria

The Clinical Outcome of BiCRI in the Treatment of Chondral and Osteochondral Lesions

Articular Cartilage Disorder of Knee

Based on the previous successful experiences, the investigators like to extend our patient population. In this study, the investigators aim to determine the safety and effectiveness of the Biphasic Cartilage Repair Implant (BiCRI) in the treatment of chondral and osteochondral lesions of the knee, including but not limited to more than one (1) lesion and the lesion that had been treated with microfracture or mosaicplasty but failed.

Recruiting6 enrollment criteria

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects...

Chondral DefectOsteochondritis Dissecans (OCD)2 more

The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of patients aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the knee.

Recruiting11 enrollment criteria

A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle...

Chondral DefectArticular Cartilage Defect1 more

The aim of the study is to compare whether JointRep® plus microfracture is more effective than microfracture alone when treating symptomatic focal articular cartilage lesions in the knee (femoral condyles or trochlea).

Recruiting43 enrollment criteria

Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee

Knee InjuriesCartilage Injury2 more

Multi-center, prospective, concurrently controlled, non-randomized, double-blind (patient and assessor). Treatment of large chondral lesions in the knee with microfracture plus the Chondro-Gide® ACC is non-inferior to treatment of small chondral lesions treated with microfracture alone.

Recruiting24 enrollment criteria

Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects...

Articular Cartilage Defects in the Knee Joint

Multicenter, open-label, controlled, non-randomized, double arm trial with a prospective treatment arm (GelrinC). This study compares the efficacy and safety of GelrinC to a historical control arm (microfracture) in the treatment of cartilage defects in the knee.

Active14 enrollment criteria

HyaloFAST Trial for Repair of Articular Cartilage in the Knee

Defect of Articular Cartilage

The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.

Active43 enrollment criteria

BioPoly® RS Partial Resurfacing Patella Registry Study

Cartilage Disease

The data registry will increase the knowledge of outcomes for treatment of focal cartilage defects of the patella treated with the BioPoly RS Patella Implant and will allow monitoring of the clinical safety and performance of the device and surgical implantation kit

Recruiting17 enrollment criteria
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