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Active clinical trials for "Cartilage Diseases"

Results 61-68 of 68

Sampling Biomarkers in Meniscus Injury to the Knee

Cartilage Diseases

The diagnosis of clinically-significant meniscal tears of the knee remains challenging, and it is unknown why only some injuries become painful. The limitations of diagnostic magnetic resonance imaging result in arthroscopy that is not always beneficial. Elucidation of biochemical pathways underlying pain in this condition may aid patient selection for surgery and provide pharmacotherapeutic targets. Cytokines may be involved in pain following meniscus injury and diagnostic cytokine assay may help physicians differentiate patients that may benefit from arthroscopy from those that may not.

Completed4 enrollment criteria

Comparison of BioCartilage Versus Marrow Stimulating Procedure for Cartilage Defects of the Knee...

Defect of Articular Cartilage

Subjects will be selected among the investigators' patient population who are already scheduled to receive a marrow stimulating procedure (MSP), with or without the addition of BioCartilage. During the surgical operation for MSP, a portion of the patient's blood is taken out and used to form a patch to cover a cartilage defect of the knee. Currently it is considered standard of care to either form the patch using only a portion of the patient's blood, or form the patch using a portion of the patient's blood combined with an FDA-approved augmentation such as BioCartilage. This study will collect outcomes data and MRI for patients that are undergoing MSP with and without BioCartilage augmentation, then compare the data between those who received BioCartilage and those who did not. The primary endpoint is to determine whether subjects receiving a marrow stimulating procedure (MSP) augmented with BioCartilage have improved outcomes (measured using quality of life indicators, functional outcomes, and MRI) compared to subjects who receive MSP without the use of BioCartilage.

Completed10 enrollment criteria

Is Lower Limb Neuromotor Control Diverse in Females With PF OA Contrasted With Asymptomatic Controls...

Chondromalacia Patellae

Objective: to investigate whether females with PF OA descend stairs with different muscular recruitment strategies contrasted with similar aged healthy females. Methods: An observational comparative study will be conducted with thirty females with PF OA and 10 healthy ones. The onset times and electromyography (EMG) duration of multifidus, transversus abdominus (TrA), gluteus medius (GM), and vasti muscles will be measured by quantitative EMG during stair descent task. hypothesis: Investigators hypothesize that there won't be a significant difference between females with PF OA and their matched healthy group regarding the onset times and duration of vastus medialis obliqus (VMO), vastus lateralis (VL), gluteus medius (GM), multifidus, and transversus abdominus (TrA), during stair descent task.

Completed11 enrollment criteria

Temporal Activation of Core Muscles and Vasti in Isolated Patellofemoral Osteoarthritis

Chondromalacia Patellae

Objective: To compare the temporal muscle activation between females with PF OA and normal controls during stair ascent. Methods: An observational comparative study was conducted with thirty-one females with PF OA and 11 healthy ones. The onset times of multifidus, transversus abdominus (TrA), gluteus medius (GM), and vasti muscles were measured by quantitative Electromyography during stair ascent task. hypothesis: Investigators hypothesized that there won't be a significant difference between females with PF OA and their matched healthy group regarding the onset times of vastus medialis obliqus (VMO), vastus lateralis (VL), gluteus medius (GM), multifidus, and transversus abdominus (TrA), during stair ascent task.

Completed10 enrollment criteria

Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee

Cartilage Diseases

This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy. The presence of the complex in the synovial fluid of the knee is sensitive and specific for the painful state compared with similar aged controls. The absence of the complex in asymptomatic controls makes it a useful biomarker for the disease state.

Completed6 enrollment criteria

Articular Sonography: Healthy Subjects Versus Rheumatoid Arthritis Patients

Disorders of SynoviumMultiple Sites7 more

The purpose of this study is to establish the normality of sonographic synovial measures in joints more affected in rheumatoid arthritis patients and establish, in those joints, a sonographic value of synovium predictive of rheumatoid arthritis.

Completed9 enrollment criteria

the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee

Defect of Articular CartilageArticular Cartilage Disorder of Knee2 more

The purpose of this study is to evaluate safety and efficacy of Chondron(autologous cultured Chondrocyte) by comparing between Chondron implantation and Microfracture.

Unknown status4 enrollment criteria

Prevalence of Chondromalacia Patella Among Adolescent Dancers - Correlation Between Symptoms and...

ChondromalaciaCartilage Diseases

Comparing the physical and sonographic findings of dancers with Chondromalacia patella to non-dancers athletes.

Unknown status13 enrollment criteria
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